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AC133, a novel marker for human hematopoietic stem and progenitor cells.
TLDR
AC133-selected cells engraft successfully in a fetal sheep transplantation model, and human cells harvested from chimeric fetal sheep bone marrow have been shown to successfully engraft secondary recipients, providing evidence for the long-term repopulating potential of AC133(+) cells. Expand
Differentiation and proliferation of hematopoietic stem cells.
TLDR
This simple model fits the understanding of the interactions of growth factors with hematopoietic progenitors and risks oversimplification of a very complex process. Expand
Total body irradiation selectively induces murine hematopoietic stem cell senescence.
TLDR
Results provide the first direct evidence demonstrating that IR exposure can selectively induce HSC senescence, and suggest that p21(Cip1/Waf1), p19(Arf), and p16(Ink4a) may play an important role in IR-induced senescences in HSCs. Expand
Differentiation and proliferation of hematopoietic stem cells.
TLDR
This simple model fits the understanding of the interactions of growth factors with hematopoietic progenitors and risks oversimplification of a very complex process. Expand
Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle.
TLDR
It is proposed that hematopoietic progenitors and stem cells in the muscle tissue are of BM origin but their transition from BM to muscle may be a slow process. Expand
Reversible expression of CD34 by murine hematopoietic stem cells.
TLDR
It is shown that CD34 expression reflects the activation state of hematopoietic stem cells and that this is reversible, and activated stem cells express CD34. Expand
Hemorrhage, Impaired Hematopoiesis, and Lethality in Mouse Embryos Carrying a Targeted Disruption of the Fli1Transcription Factor
TLDR
In vivo evidence is provided for the role of Fli1 in the regulation of hematopoiesis and hemostasis in mouse embryos homozygous for a targeted disruption in the Ets family member, Fli 1. Expand
Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.
TLDR
Results indicate that IL-3 and IL-6 act synergistically to support the proliferation of hemopoietic progenitors and that at least part of the effect results from a decrease in the G0 period of the individual stem cells. Expand
Human bone marrow CD34- cells engraft in vivo and undergo multilineage expression that includes giving rise to CD34+ cells.
TLDR
It is demonstrated that the CD34- fraction of normal human bone marrow contains cells capable of engraftment and differentiation into CD34+ progenitors and multiple lymphohematopoietic lineages in primary and secondary hosts. Expand
Reversible expression of CD34 by adult human bone marrow long-term engrafting hematopoietic stem cells.
TLDR
The finding that both CD34(-) andCD34(+) cells from primary/secondary groups engraft secondary/tertiary hosts indicates that CD34 expression on human HSC is reversible, a process that does not impair HSC function in vivo. Expand
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