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Thrombopoietin, human

Known as: MPL Ligand, TSF, Megakaryocyte Colony Stimulating Factor 
A substance made by the body that helps make blood cells, especially platelets. A form of TPO made in the laboratory is called recombinant human TPO… 
National Institutes of Health

Related topics

Related topics

19 relations
Bone MarrowCell Differentiation processCytokine GeneCytokine Receptor Binding

Broader (1)

Thrombopoietin

Narrower (1)

recombinant human thrombopoietin

Papers overview

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Review
2006
Review
2006
ITP in the 21st century.
  • D. Beardsley
  • Hematology. American Society of Hematology…
  • 2006
  • Corpus ID: 13504608
Immune (or idiopathic) thrombocytopenic purpura (ITP) is commonly encountered by the practicing hematologist. Clinical management… 
Review
1999
Review
1999
The enigmatic megakaryocyte gradually reveals its secrets.
The recent cloning of thrombopoietin has brought many insights into the cellular and molecular mechanisms of megakaryocyte and… 
1998
1998
Thrombopoietin serum concentration in patients with reactive and myeloproliferative thrombocytosis
Abstract We wished to test whether thrombopoietin (TPO) is entirely regulated by receptor binding or if other factors may play a… 
1998
1998
A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen-repopulating cells at the transient…
Thrombopoietin (TPO) has been used in preclinical myelosuppression models to evaluate the effect on hematopoietic reconstitution… 
Highly Cited
1997
Highly Cited
1997
Characterization of the Human Thrombopoietin Gene Promoter
Thrombopoietin (TPO), the ligand for c-Mpl, is a cytokine that regulates megakaryocyte growth and development. We have cloned the… 
1997
1997
Thrombopoietin induces activation of the phosphatidylinositol‐3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL
Thrombopoietin (TPO) promotes megakaryocyte growth and development. Its receptor, c‐MPL, is restricted to cells of megakaryocytic… 
1996
1996
Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation.
Megakaryocyte growth and development factor (MGDF) is a recently characterized ligand for the cell surface receptor mpl. We have… 
Highly Cited
1995
Highly Cited
1995
Thrombopoietin induces activation of at least two distinct signaling pathways
Highly Cited
1995
Highly Cited
1995
Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines.
Recently, we purified rat thrombopoietin (TPO) from plasma of irradiated rats (XRP) by measuring its activity that stimulated the… 
1995
1995
Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected…
Recently, the ligand for c-mpl, a member of the family of cytokine receptors, was cloned and found to be a physiologic regulator… 
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