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Obesity : Preventing and managing the global epidemic
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Sequencing of c-kit complementary DNA from five GISTs revealed mutations in the region between the transmembrane and tyrosine kinase domains, suggesting that the mutations contribute to tumor development. Expand
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
- Y. Arita, S. Kihara, +16 authors Y. Matsuzawa
- Biology, Medicine
- Biochemical and biophysical research…
- 2 April 1999
Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue. Expand
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.
A newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity is isolated. Expand
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
- K. Hotta, T. Funahashi, +18 authors Y. Matsuzawa
- Arteriosclerosis, thrombosis, and vascular…
- 1 June 2000
Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects. Expand
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia.
- C. Weyer, T. Funahashi, +4 authors P. A. Tataranni
- The Journal of clinical endocrinology and…
- 1 May 2001
It is confirmed that obesity and type 2 diabetes are associated with low plasma adiponectin concentrations in different ethnic groups and indicate that the degree of hypoadiponectinemia is more closely related to thedegree of insulin resistance and hyperinsulinemia than to the level of adiposity and glucose intolerance. Expand
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
Testing the hypothesis that long-term use of eicosapentaenoic acid (EPA) is effective for prevention of major coronary events in hypercholesterolaemic patients in Japan who consume a large amount of fish found it to be a promising treatment. Expand
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
Thiazolidinediones (TZDs) might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponECTin promoter. Expand
The metabolic syndrome: a global public health problem and a new definition.
- P. Zimmet, D. Magliano, Y. Matsuzawa, G. Alberti, J. Shaw
- Journal of atherosclerosis and thrombosis
- 25 December 2005
The International Diabetes Federation (IDF) has recently proposed a new definition for the metabolic syndrome, which is applicable to populations around the world and will help resolve the confusion caused by the number of earlier attempts to define this important entity. Expand
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
The results indicate that adiponectin/ACRP30 deficiency and high TNF-α levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance. Expand