• Publications
  • Influence
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the human digestive tract, but their molecular etiology and cellular origin are unknown. Sequencing of c-kitExpand
  • 3,938
  • 187
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
We isolated the human adipose-specific and most abundant gene transcript, apM1 (Maeda, K., et al., Biochem. Biophys. Res. Commun. 221, 286-289, 1996). The apM1 gene product was a kind of solubleExpand
  • 4,450
  • 156
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.
Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceralExpand
  • 1,182
  • 140
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed the plasma adiponectin concentrations in age- and body massExpand
  • 3,010
  • 98
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia.
Plasma concentrations of adiponectin, a novel adipose-specific protein with putative antiatherogenic and antiinflammatory effects, were found to be decreased in Japanese individuals with obesity,Expand
  • 3,305
  • 94
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
BACKGROUND Epidemiological and clinical evidence suggests that an increased intake of long-chain n-3 fatty acids protects against mortality from coronary artery disease. We aimed to test theExpand
  • 1,841
  • 85
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
Insulin resistance and its dreaded consequence, type 2 diabetes, are major causes of atherosclerosis. Adiponectin is an adipose-specific plasma protein that possesses anti-atherogenic properties,Expand
  • 1,612
  • 46
Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.
We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. AdiponectinExpand
  • 1,213
  • 46
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Here we investigated the biological functions of adiponectin/ACRP30, a fat-derived hormone, by disrupting the gene that encodes it in mice. Adiponectin/ACRP30-knockout (KO) mice showed delayedExpand
  • 1,973
  • 44
The metabolic syndrome: a global public health problem and a new definition.
The constellation of metabolic abnormalities including centrally distributed obesity, decreased high-density lipoprotein cholesterol (HDL-C), elevated triglycerides, elevated blood pressure (BP), andExpand
  • 676
  • 42