Thrombopoietin

Known as: Thrombocytopoiesis-Stimulating Factor, mpl Ligand, Thrombocytopoietin 
A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet… (More)
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Highly Cited
2004
Highly Cited
2004
The molecular pathways involved in the differentiation of hematopoietic progenitors are unknown. Here we report that chemokine… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE The objective of this study was to evaluate the tolerability, pharmacodynamics, and pharmacokinetics of AMG 531, a… (More)
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Highly Cited
1997
Highly Cited
1997
Thrombopoietin (TPO) is the primary hematopoietic growth factor involved in the regulation of platelet production. Although the… (More)
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Highly Cited
1997
Highly Cited
1997
To evaluate the effects of long-term, high-dose exposure to thrombopoietin (TPO), lethally irradiated mice were grafted with bone… (More)
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Highly Cited
1996
Highly Cited
1996
Recently, the ligand for the Mpl receptor (ML) was identified to be thrombopoietin, the principal regulator of… (More)
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Highly Cited
1995
Highly Cited
1995
Thrombopoietin (c-Mpl ligand) has recently been purified and is considered to be the humoral regulator of platelet production. To… (More)
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Highly Cited
1995
Highly Cited
1995
c-Mpl is a member of the cytokine receptor superfamily, expressed primarily on hematopoietic cells. Recently, the c-Mpl ligand… (More)
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Highly Cited
1994
Highly Cited
1994
THE development of blood cells including expansion of megakaryocyte progenitor cells requires the interplay of marrow stromal… (More)
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Highly Cited
1994
Highly Cited
1994
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively… (More)
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