purine nucleotide biosynthetic process

Known as: purine nucleotide formation, purine nucleotide anabolism, purine nucleotide biosynthesis 
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a… (More)
National Institutes of Health

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negative regulation of purine nucleotide biosynthetic processpositive regulation of purine nucleotide biosynthetic process

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Highly Cited
2007
Highly Cited
2007
Quantitative proteomics and transcriptomics of anaerobic and aerobic yeast cultures reveals post-transcriptional regulation of key cellular processes.
Saccharomyces cerevisiae is unique among yeasts in its ability to grow rapidly in the complete absence of oxygen. S. cerevisiae… (More)
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Highly Cited
2003
Highly Cited
2003
Riboswitches Control Fundamental Biochemical Pathways in Bacillus subtilis and Other Bacteria
Riboswitches are metabolite binding domains within certain messenger RNAs that serve as precision sensors for their corresponding… (More)
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Highly Cited
2003
Highly Cited
2003
CD 28-dependent Rac 1 activation is the molecular target of azathioprine in primary human CD 4 + T lymphocytes
Azathioprine and its metabolite 6-mercaptopurine (6-MP) are widely used as immunosuppressive and anti-inflammatory agents in… (More)
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Highly Cited
2000
Highly Cited
2000
A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma.
Anaplastic lymphoma kinase (ALK)-positive lymphomas ("ALKomas") constitute a distinct molecular and clinicopathological entity… (More)
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Highly Cited
2000
Highly Cited
2000
Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide…
The non-Hodgkin lymphoma (NHL) subtype anaplastic large-cell lymphoma (ALCL) is frequently associated with a t(2;5)(p23;q35) that… (More)
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Review
1992
Review
1992
De novo purine nucleotide biosynthesis.
 
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Highly Cited
1987
Highly Cited
1987
Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis.
An approximately 16-kilobase pair region of the Bacillus subtilis chromosome at 55 degrees containing genes for de novo purine… (More)
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Highly Cited
1981
Highly Cited
1981
Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.
Cultured monkey (TC7) and mouse (3T6) cells synthesize an Excherichia coli enzyme, xanthine-guanine phosphoribosyltransferase… (More)
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Highly Cited
1980
Highly Cited
1980
Expression of a bacterial gene in mammalian cells.
Transfection of cultured monkey kidney cells with recombinant DNA constructed with a cloned Escherichia coli gene that codes for… (More)
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1974
1974
Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.
Brief exposure to 6-mercaptopurine (MP) elicits a de layed cytotoxic reaction in cultures of mouse lymphoma L5 178Y cells; the… (More)
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