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Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
- W. Shi, N. Munagala, S. Almo
- Chemistry, BiologyBiochemistry
- 13 June 2000
TLDR
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).
- C. Takeuchi, Byung Gyu Kim, N. Miller
- Biology, ChemistryJournal of medicinal chemistry
- 7 March 2013
TLDR
Adenosine is the primary precursor of all purine nucleotides in Trichomonas vaginalis.
- N. Munagala, Ching C. Wang
- BiologyMolecular and biochemical parasitology
- 3 April 2003
Rational design of selective submicromolar inhibitors of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase.
- A. Aronov, N. Munagala, P. Ortiz de Montellano, I. Kuntz, C. Wang
- Biology, ChemistryBiochemistry
- 25 April 2000
TLDR
Virtual Screening of Combinatorial Libraries across a Gene Family: in Search of Inhibitors of Giardia lamblia Guanine Phosphoribosyltransferase
- A. Aronov, N. Munagala, I. Kuntz, Ching C. Wang
- Biology, ChemistryAntimicrobial Agents and Chemotherapy
- 1 September 2001
TLDR
Altering the purine specificity of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus by structure-based point mutations in the enzyme protein.
- N. Munagala, C. Wang
- Biology, ChemistryBiochemistry
- 24 November 1998
TLDR
The purine nucleoside phosphorylase from Trichomonas vaginalis is a homologue of the bacterial enzyme.
- N. Munagala, Ching C. Wang
- Biology, ChemistryBiochemistry
- 25 July 2002
TLDR
Converting the Guanine Phosphoribosyltransferase from Giardia lamblia to a Hypoxanthine-guanine Phosphoribosyltransferase*
- N. Munagala, A. Sarver, C. Wang
- Biology, ChemistryThe Journal of Biological Chemistry
- 24 November 2000
TLDR
Steady-state kinetics of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus: the role of threonine-47.
- N. Munagala, M. Chin, C. Wang
- BiologyBiochemistry
- 6 March 1998
TLDR
Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan.
- J. R. Somoza, A. Skillman, C. Wang
- BiologyBiochemistry
- 21 April 1998
TLDR
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