C. Wang

Publications238
h-index49
Citations8,030
Highly Influential Citations272
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Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.
The 2.8 A resolution crystal structure of the bacteriophage RB69 gp43, a member of the eukaryotic pol alpha family of replicative DNA polymerases, shares some similarities with other polymerases but…
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Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69
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Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis.
  • C. Wang
  • Biology
    Annual review of pharmacology and toxicology
  • 1995
TLDR
The African trypanosomes are among the most extensively studied parasitic protozoa to date and can be viewed as attractive targets for antitrypanosomal chemotherapy.
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Discovery of a specific double-stranded RNA virus in Giardia lamblia.
  • A. Wang, C. Wang
  • Biology
    Molecular and biochemical parasitology
  • 1 December 1986
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Giardiavirus double-stranded RNA genome encodes a capsid polypeptide and a gag-pol-like fusion protein by a translation frameshift.
TLDR
Giardiavirus genomic cDNA was constructed and its sequence revealed the presence of two large open reading frames that are separated by a -1 frameshift and share an overlap of 220 nt, and a heptamer-pseudoknot structure similar to those found at ribosomal slippage sites in retroviruses and yeast killer virus was identified within this overlap.
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Dissociation of Cytokinesis Initiation from Mitotic Control in a Eukaryote
TLDR
A novel mechanism of cytokinesis initiation in the trypanosome that may serve as a useful model for further in-depth investigations is revealed and an exposed region of TbPLK at the anterior tip of the cell may provide the trigger of cytokineis.
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Chaperone-like activity of protein disulfide isomerase in the refolding of a protein with no disulfide bonds.
TLDR
It is suggested that upon dilution, denatured GAPDH is faced with two competing processes of correct folding and assembly to yield the native enzyme and non-productive association of the partially refolded species to form aggregates.
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Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes, and glycosomes
TLDR
Results indicate that at least one of the signals, and therefore the mechanism, for protein translocation into peroxisomes, glyoxysomes, and glycosomes has been conserved, lending support to a common evolutionary origin for these microbodies.
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The double-stranded RNA in Trichomonas vaginalis may originate from virus-like particles.
  • A. Wang, C. Wang
  • Biology
    Proceedings of the National Academy of Sciences…
  • 1 October 1986
A linear 5.5-kilobase double-stranded RNA, identified in many strains and isolates of the parasitic protozoan Trichomonas vaginalis in a previous study, is found largely intact in…
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Inhibition of pyruvate‐ferredoxin oxidoreductase gene expression in Giardia lamblia by a virus‐mediated hammerhead ribozyme
TLDR
The presence of PFOR enhances the anaerobic growth of Giardia with an increased susceptibility towards metronidazole and the feasibility of using a viral vector to express a ribozyme targeted at a specific mRNA in G. lamblia is demonstrated for the first time.
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