protein tyrosine phosphatase activity

Known as: PTP-phosphatase activity, tyrosylprotein phosphatase activity, PTPase activity 
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]
National Institutes of Health

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4 relations
Protein Tyrosine Phosphatasenegative regulation of protein tyrosine phosphatase activitypositive regulation of protein tyrosine phosphatase activity

Broader (1)

peptidyl-tyrosine dephosphorylation

Papers overview

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2013
2013
Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical.
Substantial evidence suggests that transient production of reactive oxygen species (ROS) such as hydrogen peroxide (H(2)O(2)) is… (More)
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Highly Cited
2003
Highly Cited
2003
Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling.
Zinc is an effector of insulin/IGF-1 signaling and has insulinomimetic effects, the molecular basis of which is not understood… (More)
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Highly Cited
1999
Highly Cited
1999
Activation of phosphotyrosine phosphatase activity attenuates mitogen-activated protein kinase signaling and inhibits c-FOS and nitric oxide synthase expression in macrophages infected with…
Intracellular protozoan parasites of the genus Leishmania antagonize host defense mechanisms by interfering with cell signaling… (More)
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1997
1997
Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts.
Signaling pathways mediated by tyrosine phosphorylation and dephosphorylation have been reported to be involved in the regulation… (More)
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1994
1994
Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance.
Particulate and cytosolic protein tyrosine phosphatase (PTPase) activity was measured in skeletal muscle from 15 insulin… (More)
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1994
1994
Autophosphorylation-activated protein kinase inactivates the protein tyrosine phosphatase activity of protein phosphatase 2A.
Phosphorylation of the catalytic subunit of protein phosphatase 2A (PP2A) on threonines with a distinct autophosphorylation… (More)
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Highly Cited
1992
Highly Cited
1992
Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate in vitro.
Acute (10-30 min) treatment of intact rat hepatoma (Fao) cells with H2O2, inhibits in vivo protein tyrosine phosphatase activity… (More)
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Highly Cited
1992
Highly Cited
1992
The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase.
The signalling mechanism and cellular targets of the AT2 receptor are still unknown. We report that angiotensin II (Ang II… (More)
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Highly Cited
1990
Highly Cited
1990
The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells.
H2O2 and vanadate are known insulinomimetic agents. Together they induce insulin's bioeffects with a potency which exceeds that… (More)
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Highly Cited
1989
Highly Cited
1989
Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.
CD45 is a family of high molecular weight leukocyte cell surface glycoproteins. Recently, two related subregions of the… (More)
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