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protein tyrosine phosphatase activity

Known as: PTP-phosphatase activity, tyrosylprotein phosphatase activity, PTPase activity 
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]
National Institutes of Health

Related topics

Related topics

4 relations
Protein Tyrosine Phosphatasenegative regulation of protein tyrosine phosphatase activitypositive regulation of protein tyrosine phosphatase activity

Broader (1)

peptidyl-tyrosine dephosphorylation

Papers overview

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2001
2001
The activation of the phosphotyrosine phosphatase eta (r-PTP eta) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation.
The aim of this study was the characterization of the intracellular effectors of the antiproliferative activity of somatostatin… 
Highly Cited
1996
Highly Cited
1996
Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors.
The signaling pathway by which GnRH acts in peripheral tumors is distinct from that in the anterior pituitary. We attempted to… 
Review
1995
Review
1995
Modulation of insulin action by vanadate: evidence of a role for phosphotyrosine phosphatase activity to alter cellular signaling
A number of vanadium compounds (vanadate, vanadyl sulfate, metavanadate) have insulin-mimicking actions bothin vitro andin vivo… 
1995
1995
Protein tyrosine phosphatase activity associates with the high affinity IgE receptor and dephosphorylates the receptor subunits, but not Lyn or Syk.
Protein tyrosine phosphorylation is an early event in the high affinity IgE receptor (Fc epsilon RI)-mediated signaling cascade… 
Highly Cited
1994
Highly Cited
1994
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
1993
1993
Rat acid phosphatase: overexpression of active, secreted enzyme by recombinant baculovirus-infected insect cells, molecular properties, and crystallization.
Rat prostatic acid phosphatase (rPAP; orthophosphoric-monoester phosphohydrolase (acid optimum), EC 3.1.3.2) was expressed in the… 
Highly Cited
1993
Highly Cited
1993
Activation of phosphotyrosine phosphatase activity by reduction of cell-substrate adhesion.
Treatment of chicken embryo fibroblasts (CEFs) with trypsin results in a dose- and time-dependent loss of phosphotyrosine from… 
1993
1993
A protein tyrosine phosphatase activity associated with the hepatocyte growth factor/scatter factor receptor.
Highly Cited
1989
Highly Cited
1989
The 18 kDa cytosolic acid phosphatase from bovine liver has phosphotyrosine phosphatase activity on the autophosphorylated epidermal growth factor receptor
1989
1989
Purification and characterization of a protein-phosphotyrosine phosphatase from rat spleen which dephosphorylates and inactivates a tyrosine-specific protein kinase.
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