Expression of oestrogen receptor-alpha and -beta in ovarian endometriomata.
- J. Fujimoto, R. Hirose, H. Sakaguchi, T. Tamaya
- BiologyMolecular human reproduction
In ovarian endometriomata, oestrogen action via ER- alpha cascades seems to be partially damaged, as the expression of ER-alpha mRNA does not respond to endocrinological alterations during the menstrual cycle, while the relative over-expression ofER-beta might be related to a unique oestrogens-dependent growth and spreading of ovarian endometriciomata.
A case-control study of uterine endometrial cancer of pre- and post-menopausal women.
Findings indicate that untreated ovarian dysfunction such as PCOS with unopposed estrogenic action in the endometrium may be associated with development and growth of EC in younger women, yet abnormality of p53 gene may be more concerned with the development of the post-menopausal EC, independently of sex steroid influence.
Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors.
- A. Imai, H. Takagi, S. Horibe, T. Fuseya, T. Tamaya
- BiologyJournal of Clinical Endocrinology and Metabolism
- 1 September 1996
The apparent inhibition by GnRH of the ADP-ribosylation demonstrated that GnRH resolved the alpha-subunit of the Gi to GTP-bound form in the membranes, which demonstrates the coupling of GnRH receptor to Gi protein subfamily.
Gonadotropin-releasing hormone analog repairs reduced endometrial cell apoptosis in endometriosis in vitro.
- A. Imai, A. Takagi, T. Tamaya
- Medicine, BiologyAmerican Journal of Obstetrics and Gynecology
- 1 May 2000
Exposure to gonadotropin-releasing hormone results in changes of the sensitivity of endometriotic endometrium to spontaneous apoptosis; these changes in sensitivity may, in turn, release endometrial cells from resistance to apoptosis and result in reduced survival and growth.
Evidence for tight coupling of gonadotropin-releasing hormone receptor to stimulated Fas ligand expression in reproductive tract tumors: possible mechanism for hormonal control of apoptotic cell…
- A. Imai, A. Takagi, S. Horibe, H. Takagi, T. Tamaya
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
- 1 February 1998
Data demonstrate the functional coupling of stimulated Fas ligand expression to GnRH receptor activation to promote apoptotic cell death through attack on intratumoral Fas-positive cells that could, at least in part, account for the antiproliferative action of the hormone.
Synergistic effects of danazol and mifepristone on the cytotoxicity of UCN-01 in hormone-responsive breast cancer cells.
- Y. Yokoyama, A. Shinohara, T. Tamaya
- Biology, MedicineAnticancer Research
- 1 September 2000
It is suggested that danazol or mifepristone might enhance the antitumor activity of UCN-01 in hormone-dependent cancer cells by interacting with PR.
[Angiogenic factors in endometriosis].
- J. Fujimoto, T. Tamaya
- MedicineNihon rinsho. Japanese journal of clinical…
Evidence for coupling of phosphotyrosine phosphatase to gonadotropin‐releasing hormone receptor in ovarian carcinoma membrane
- A. Imai, Hiroshi Takagi, T. Furui, S. Horibe, Tatsuo Fuseya, T. Tamaya
- Biology, MedicineCancer
To examine whether Gn‐RHR mediates direct antiproliferative effects, stimulatory regulation by Gn‐RH of phosphotyrosine phosphatase activity in plasma membranes isolated from ovarian carcinoma samples was attempted.
In vitro antifungal activity of FK463, a new water-soluble echinocandin-like lipopeptide.
Results from pre-clinical evaluations performed to date indicate that FK463 should be a potent parenteral antifungal agent.