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MHC class I (MHC I) antigen presentation of exogenous antigens (so called "cross presentation") is a central mechanism of CD8… Expand BACKGROUND
Ethanol and cocaine are widely abused drugs triggering long-lasting changes in neuronal circuits and synaptic… Expand Reactive oxygen species (ROS) have been shown to be toxic but also function as signaling molecules in a process called redox… Expand The proteasome is a complex multisubunit protease that plays a major role in the degradation of proteins in eukaryotic cells… Expand Taurine depletion leads to impaired mitochondrial function, as characterized by reduced ATP production and elevated superoxide… Expand Oxidative stress and the ubiquitin-proteasome system play a key role in the pathogenesis of Parkinson disease. Although the… Expand Osteosarcoma is a most common highly malignant bone tumor in children and adolescents. Polyphyllin I (PPI) is an ethanol… Expand Melatonin (N‐acetyl‐5‐methoxytryptamine) has recently gained attention as an anticancer agent and for combined cancer therapy. In… Expand Alcohol consumption exacerbates the course of hepatitis C viral (HCV) infection, worsens outcomes and contributes to the… Expand We tested the possibility that proteasome inhibition may reverse preexisting cardiac hypertrophy and improve remodeling upon… Expand