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prostaglandin-endoperoxide synthase activity

Known as: fatty acid cyclooxygenase activity, (PG)H synthase activity, prostaglandin synthase activity 
Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. [EC:1.14.99.1]
National Institutes of Health

Related topics

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2 relations
Prostaglandin-Endoperoxide Synthasecyclooxygenase 1

Papers overview

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Highly Cited
1995
Highly Cited
1995
Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?
Nonsteroidal antiinflammatory drugs (NSAIDs) have considerable potential as chemopreventive agents for colorectal cancer. Recent… 
Highly Cited
1993
Highly Cited
1993
Effect of stress on the antioxidant enzymes and gastric ulceration
The effect of cold-restraint stress on the antioxidant enzymes of the rat gastric mucosa was studied with a view to finding out… 
Highly Cited
1993
Highly Cited
1993
Prostaglandin G/H synthase isoenzyme 2 expression in fibroblasts: regulation by dexamethasone, mitogens, and oncogenes.
Mitogens increase prostaglandin synthesis in fibroblasts. In the present studies, transcriptional activation of the prostaglandin… 
Highly Cited
1980
Highly Cited
1980
Mode of action of sesquiterpene lactones as anti-inflammatory agents.
Sesquiterpene lactones containing an alpha-methylene-gamma-lactone moiety were shown to be potent inhibitors of carrageenan… 
Highly Cited
1976
Highly Cited
1976
Altered platelet function in diabetes mellitus.
An increased sensitivity of platelets to aggregation from ADP and epinephrine is described in diabetics with or without vascular… 
Highly Cited
1975
Highly Cited
1975
A CHEMOTACTIC ROLE FOR PROSTAGLANDINS RELEASED FROM POLYMORPHONUCLEAR LEUCOCYTES DURING PHAGOCYTOSIS
1 Prostaglandin E1 is chemotactic at concentrations down to 10 ng/ml for rabbit polymorphonuclear (PMN) leucocytes… 
Highly Cited
1975
Highly Cited
1975
Periovulatory changes in ovarian prostaglandin formation and their hormonal control in the rat.
Highly Cited
1973
Highly Cited
1973
Radioimmunological assay of prostaglandin synthetase activity.
Highly Cited
1972
Highly Cited
1972
Prostaglandin synthetase activity in the rat stomach fundus. Activation by L-norepinephrine and related compounds.
Highly Cited
1971
Highly Cited
1971
Properties of a novel preparation of prostaglandin synthetase from sheep seminal vesicles.
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