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Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes.
TLDR
It is concluded that FK-506 increases the fraction of SR Ca2+ released during normal twitches and enhances the rate of SRCa2+ release during rest, consistent with an important SR-stabilizing effect of FKBP in intact rat ventricular myocytes. Expand
Vascular endothelial cells and granulopoiesis: interleukin-1 stimulates release of G-CSF and GM-CSF.
TLDR
It is concluded that IL 1-stimulated endothelial cells release both G and GM-CSF and that these are the only granulopoietic factors detectable in clonogenic assays released by these cells in vitro. Expand
Contraction and intracellular Ca2+, Na+, and H+ during acidosis in rat ventricular myocytes.
TLDR
It is concluded that a major cause of the initial decline of the twitch during acidosis is a decrease in the response of the contractile proteins to Ca2+ due to the decrease of intracellular pH activating the Na(+)-H+ exchange mechanism. Expand
Mechanical alternans during acidosis in ferret heart muscle.
TLDR
The observation that a Ca2(+)-activated inward current also shows alternation during mechanical alternans provides a possible mechanism for the link between Ca2+ and action potential duration and the observation that decreasing stimulation rate can abolish the alternans. Expand
The relationship between contraction and intracellular sodium in rat and guinea‐pig ventricular myocytes.
TLDR
The similarity of the relation between twitch shortening and aNai during the staircase and on application of strophanthidin suggests that the progressive increase in the strength of contraction during the stairs was also linked to the rise in aNAI. Expand
A CHEMOTACTIC ROLE FOR PROSTAGLANDINS RELEASED FROM POLYMORPHONUCLEAR LEUCOCYTES DURING PHAGOCYTOSIS
TLDR
It is concluded that in some forms of inflammation, prostaglandin E1 may play a controlling role in cellular migration. Expand
The effect of acidosis on the relationship between Ca2+ and force in isolated ferret cardiac muscle.
TLDR
It is suggested that in intact cardiac muscle the major effect of a mild acidosis is to decrease the sensitivity of the contractile proteins to Ca2+, hence decreasing the number of bound cross‐bridges. Expand
Ca flux, contractility, and excitation-contraction coupling in hypertrophic rat ventricular myocytes.
TLDR
Un unloaded myocyte contraction was depressed in these hypertrophic hearts, but Ca transport was little altered, at 1 mM [Ca]o, and reduction of [ Ca]o to 0.5 mM appears to unmask a depressed fractional SR Ca release in response to a given ICa trigger and SR Ca load. Expand
Protein kinase C-alpha and -epsilon modulate connexin-43 phosphorylation in human heart.
TLDR
In the human heartPKC- alpha, PKC- epsilon, and Cx-43 appear to form a closely associated complex, with PKC activity significantly above endogenous levels in the co-immunoprecipitated CX-43 complexes. Expand
Interleukin 1 stimulates granulocyte macrophage colony-stimulating activity release by vascular endothelial cells.
TLDR
It is concluded thatIL-1 induces the release of CSA by vascular endothelial cells, that IL-1 is constitutively produced by monocytes in vitro, and that MRA and IL-2 are biologically, biophysically and, immunologically identical. Expand
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