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proguanil hydrochloride

Known as: Imidodicarbonimidic Diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Monohydrochloride(9CI), Hydrochloride, Proguanil, Bigumalum 
The hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
  • S. Patel, K. Kain
  • Expert review of anti-infective therapy
  • 2005
  • Corpus ID: 5773988
Increases in international travel and escalating drug resistance have resulted in a growing number of travelers at risk of… Expand
Highly Cited
2003
Highly Cited
2003
The increased spread of drug resistant malaria highlights the need for alternatives for treatment and chemoprophylaxis. The… Expand
Highly Cited
2002
Highly Cited
2002
The increasing prevalence of resistance to antimalarial drugs reduces options for malaria prophylaxis. Atovaquone/proguanil… Expand
Highly Cited
1999
Highly Cited
1999
Malaria poses a major health risk to people who are exposed to infection in malaria-endemic areas. A randomized, double-blind… Expand
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1999
1999
Chloroquine-resistant Plasmodium vivax malaria has been reported in several geographical areas. The P. vivax life-cycle includes… Expand
1999
1999
Atovaquone and proguanil hydrochloride are blood schizonticides that demonstrate in vitro synergy against drug-resistant strains… Expand
Highly Cited
1998
Highly Cited
1998
Currently recommended prophylactic regimens for Plasmodium falciparum malaria are associated with a high incidence of adverse… Expand
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1998
1998
AIMS To investigate the relationship between proguanil metabolic ratio (MR, proguanil/cycloguanil) and CYP2C19 genotype in a… Expand
Highly Cited
1995
Highly Cited
1995
The S‐mephenytoin hydroxylase has recently been identified as cytochrome P450 2C19 (CYP2C19). This enzyme metabolizes mephenytoin… Expand
Highly Cited
1988
Highly Cited
1988
One hundred and ninety students aged 6 to 18 at a boarding school 120 km west of Nairobi in the Rift Valley participated in a… Expand