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proguanil hydrochloride

Known as: Imidodicarbonimidic Diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Monohydrochloride(9CI), Hydrochloride, Proguanil, Bigumalum 
The hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon… Expand
National Institutes of Health

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Highly Cited
2003
Highly Cited
2003
The increased spread of drug resistant malaria highlights the need for alternatives for treatment and chemoprophylaxis. The… Expand
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2002
2002
The increasing prevalence of resistance to antimalarial drugs reduces options for malaria prophylaxis. Atovaquone/proguanil… Expand
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Highly Cited
2001
Highly Cited
2001
We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride… Expand
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1999
1999
BACKGROUND Malaria is a major cause of pediatric mortality in sub-Saharan Africa. Worldwide estimates of mortality among children… Expand
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1999
1999
Atovaquone and proguanil hydrochloride are blood schizonticides that demonstrate in vitro synergy against drug-resistant strains… Expand
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1999
1999
Chloroquine-resistant Plasmodium vivax malaria has been reported in several geographical areas. The P. vivax life-cycle includes… Expand
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1999
1999
Malaria poses a major health risk to people who are exposed to infection in malaria-endemic areas. A randomized, double-blind… Expand
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1998
1998
Currently recommended prophylactic regimens for Plasmodium falciparum malaria are associated with a high incidence of adverse… Expand
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1998
1998
AIMS To investigate the relationship between proguanil metabolic ratio (MR, proguanil/cycloguanil) and CYP2C19 genotype in a… Expand
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1995
1995
The S-mephenytoin hydroxylase has recently been identified as cytochrome P450 2C19 (CYP2C19). This enzyme metabolizes mephenytoin… Expand
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