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proguanil hydrochloride

Known as: Imidodicarbonimidic Diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Monohydrochloride(9CI), Hydrochloride, Proguanil, Bigumalum 
The hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon… 
National Institutes of Health

Papers overview

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Review
2005
Review
2005
Increases in international travel and escalating drug resistance have resulted in a growing number of travelers at risk of… 
Highly Cited
2003
Highly Cited
2003
The increased spread of drug resistant malaria highlights the need for alternatives for treatment and chemoprophylaxis. The… 
Highly Cited
2002
Highly Cited
2002
The increasing prevalence of resistance to antimalarial drugs reduces options for malaria prophylaxis. Atovaquone/proguanil… 
Review
1999
Review
1999
The continuing spread of drug-resistant malaria emphasizes the need for new antimalarial drugs. Atovaquone is a broad-spectrum… 
Highly Cited
1999
Highly Cited
1999
Malaria poses a major health risk to people who are exposed to infection in malaria-endemic areas. A randomized, double-blind… 
Review
1999
Review
1999
BACKGROUND Safe and effective antimalarial drugs are needed for treatment and prophylaxis of malaria. The combination of… 
Highly Cited
1998
Highly Cited
1998
Currently recommended prophylactic regimens for Plasmodium falciparum malaria are associated with a high incidence of adverse… 
Highly Cited
1988
Highly Cited
1988
One hundred and ninety students aged 6 to 18 at a boarding school 120 km west of Nairobi in the Rift Valley participated in a…