Proguanil

Known as: Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Chlorguanid, Proguanilum 
A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite… (More)
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Highly Cited
2007
Highly Cited
2007
The origin of all mitochondria can be traced to the symbiotic arrangement that resulted in the emergence of eukaryotes in a world… (More)
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Highly Cited
2004
Highly Cited
2004
A modified fixed-ratio isobologram method for studying the in vitro interactions between antiplasmodial drugs is described. This… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE To compare the tolerability of malaria chemoprophylaxis regimens in non-immune travellers. DESIGN Randomised, double… (More)
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1998
1998
BACKGROUND The combination of atovaquone and proguanil is highly effective and safe for the treatment of Plasmodium falciparum… (More)
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Highly Cited
1997
Highly Cited
1997
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors… (More)
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1997
1997
The purpose of this study was to compare an experimental regimen of atovaquone plus proguanil with the standard regimen of… (More)
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Highly Cited
1996
Highly Cited
1996
The therapy of Plasmodium falciparum malaria continues to be a problem in many parts of Southeast Asia because of multidrug… (More)
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Highly Cited
1990
Highly Cited
1990
Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and… (More)
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Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… (More)
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