Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Proguanil

Known as: Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Chlorguanid, Proguanilum 
A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
ABSTRACT A modified fixed-ratio isobologram method for studying the in vitro interactions between antiplasmodial drugs is… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Review
2002
Review
2002
Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large differences in the pharmacokinetics of a number of… Expand
Is this relevant?
Review
2001
Review
2001
  • J. Goldstein
  • British journal of clinical pharmacology
  • 2001
  • Corpus ID: 26190851
The human CYP2Cs are an important subfamily of P450 enzymes that metabolize approximately 20% of clinically used drugs. There are… Expand
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The lack of suitable antimalarial agents to replace chloroquine and pyrimethamine/sulfadoxine threatens efforts to control the… Expand
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • table 1
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The 4'-hydroxylation of the S-enantiomer of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans. This… Expand
  • figure 2
  • figure 1
  • figure 3
  • table 1
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
A genetic polymorphism in the metabolism of the anticonvulsant drug S-mephenytoin has been attributed to defective CYP2C19… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors… Expand
  • table 1
  • figure 2
  • figure 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1996
Highly Cited
1996
The therapy of Plasmodium falciparum malaria continues to be a problem in many parts of Southeast Asia because of multidrug… Expand
Is this relevant?
Highly Cited
1990
Highly Cited
1990
Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?