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Proguanil

Known as: Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Chlorguanid, Proguanilum 
A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
National Institutes of Health

Related topics

Related topics

25 relations

Broader (2)

AntimalarialsAntimetabolites

Narrower (10)

Atovaquone / ProguanilBigumalChloriguaneMalarone
Atovaquone 250 MG / proguanil hydrochloride 100 MG Oral TabletAtovaquone 62.5 MG / proguanil hydrochloride 25 MG Oral Tablet [Malarone]Drug AllergyIn Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Sustained drug release and electrochemical performance of ethyl cellulose-magnesium hydrogen phosphate composite.
2013
2013
Antimalarial chemoprophylaxis and the risk of neuropsychiatric disorders.
Review
2008
Review
2008
Allele frequency differences of cytochrome P450 polymorphisms in a sample of New Zealand Māori.
AIMS To determine the prevalence of functional alleles for drug metabolising genes in a sample of Maori and compare allele… 
Highly Cited
2006
Highly Cited
2006
Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast.
Indoleamine 2,3-dioxygenase (IDO) is a tryptophan degradation enzyme that is emerging as an important drug target. IDO is… 
1999
1999
Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.
AIMS To compare the oxidative metabolism of (S)-mephenytoin and proguanil in vitro and to determine the involvement of various… 
Highly Cited
1993
Highly Cited
1993
Chloroquine-induced inhibition of the production of TNF, but not of IL-6, is affected by disruption of iron metabolism.
1965
1965
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. II. Triazine resistance.
Highly Cited
1965
Highly Cited
1965
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. 3. Multiple drug resistance.
Highly Cited
1963
Highly Cited
1963
CHLOROQUINE RESISTANT FALCIPARUM MALARIA IN MALAYA.
Review
1955
Review
1955
The mode of action of sulphonamides, proguanil and pyrimethamine on Plasmodium gallinaceum.
Despite the mass of information on the antimalarial action of sulphonamides, proguanil, and pyrimethamine (see Goodwin and Rollo… 
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