Allergy, parasites, and the hygiene hypothesis.
- M. Yazdanbakhsh, P. Kremsner, R. Van Ree
- BiologyScience
- 19 April 2002
The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders.
Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10
- A. V. D. Biggelaar, R. Ree, M. Yazdanbakhsh
- Medicine, BiologyThe Lancet
- 18 November 2000
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
- D. Ménard, N. Khim, O. Mercereau‐Puijalon
- Medicine, BiologyNew England Journal of Medicine
- 22 June 2016
No evidence of artemisinin resistance was found outside Southeast Asia and China, where resistance-associated K13 mutations were confined, and many African mutations appear to be neutral.
Low Interleukin-12 Activity in Severe Plasmodium falciparum Malaria
- A. Luty, D. J. Perkins, P. Kremsner
- MedicineInfection and Immunity
- 1 July 2000
The results indicate that severe but not mild P. falciparummalaria in young, nonimmune African children is characterized by down-regulated IL-12 activity, contrasting markedly with the up-regulation of both TNF and IL-10 in the same children.
Blood Group A Antigen Is a Coreceptor inPlasmodium falciparum Rosetting
- A. Barragan, P. Kremsner, M. Wahlgren, J. Carlson
- Medicine, BiologyInfection and Immunity
- 1 May 2000
An important role for A and B antigens as coreceptors in P. falciparum rosetting is suggested, as the antirosetting effect of immune sera was related to the blood group of the infected human host.
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.
- S. Agnandji, B. Lell, Preeti Vansadia
- MedicineNew England Journal of Medicine
- 13 December 2012
The RTS,S/AS01 vaccine coadministered with EPI vaccines provided modest protection against both clinical and severe malaria in young infants.
Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria
- J. Kun, B. Mordmüller, B. Lell, L. Lehman, D. Luckner, P. Kremsner
- BiologyThe Lancet
- 24 January 1998
Severe falciparum malaria in Gabonese children: clinical and laboratory features
- A. Dzeing-Ella, Pascal C Nze Obiang, M. Kombila
- MedicineMalaria Journal
- 9 January 2005
The prognostic indicators of severe falciparum malaria in Gabonese children were coma/seizures, hyperlactataemia and hypoglycaemia, and the highest case fatality rate was in children with all three of these features.
Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe.
- S. Agnandji, A. Huttner, C. Siegrist
- MedicineNew England Journal of Medicine
- 28 April 2016
RVSV-ZEBOV was reactogenic but immunogenic after a single dose and warrants further evaluation for safety and efficacy, and glycoprotein-binding antibody titers were sustained through 180 days in all participants.
Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.
- J. Kun, B. Mordmüller, P. Kremsner
- BiologyJournal of Infectious Diseases
- 1 August 2001
A point mutation in the promoter of the nitric oxide synthase 2 gene (NOS2), termed NOS2(Lambaréné) (NOS2-G954C), protects heterozygous carriers against severe malaria as effectively as the sickle…
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