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Allergy, parasites, and the hygiene hypothesis.
The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders. Expand
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.
The RTS,S/AS01 vaccine coadministered with EPI vaccines provided modest protection against both clinical and severe malaria in young infants. Expand
Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10
The anti-inflammatory cytokine, interleukin-10, induced in chronic schistosomiasis, appears central to suppressing atopy in African children. Expand
Low Interleukin-12 Activity in Severe Plasmodium falciparum Malaria
The results indicate that severe but not mild P. falciparummalaria in young, nonimmune African children is characterized by down-regulated IL-12 activity, contrasting markedly with the up-regulation of both TNF and IL-10 in the same children. Expand
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
No evidence of artemisinin resistance was found outside Southeast Asia and China, where resistance-associated K13 mutations were confined, and many African mutations appear to be neutral. Expand
Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam
Differences in the replication‐phenotype of single genotypes compared to genotype‐mixtures suggest that co‐infection with different HBV‐genotypes is associated with altered pathogenesis and clinical outcome. Expand
Blood Group A Antigen Is a Coreceptor inPlasmodium falciparum Rosetting
An important role for A and B antigens as coreceptors in P. falciparum rosetting is suggested, as the antirosetting effect of immune sera was related to the blood group of the infected human host. Expand
Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.
A point mutation in the promoter of the nitric oxide synthase 2 gene (NOS2), termed NOS2(Lambaréné) (NOS2-G954C), protects heterozygous carriers against severe malaria as effectively as the sickleExpand
Reduced interleukin-12 and transforming growth factor-beta1 in severe childhood malaria: relationship of cytokine balance with disease severity.
The results suggest that the inflammatory cascade in severe malaria is characterized by suppression of the protective effects of TGF-beta1 and IL-12, and that overproduction of TNF-alpha may promote deleterious effects, such as severe anemia. Expand