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polyglutamate camptothecin

Known as: Camptothecin Polyglutamate, PG-CPT, Polyglutamate PG-CPT 
A therapeutic formulation consisting of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, conjugated with polyglutamate… 
National Institutes of Health

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CT 2106

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CamptothecinPolyglutamic Acid
analogs & derivatives

Papers overview

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2017
2017
WATER-INSOLUBLE S-CAMPTOTHECIN OF THE CLOSED LACTONE RING FORMAND
Re. 32,518 10/1987 Miyasaka et al. ........................ 546/48 3,894,029 7/1975 Winterfeldt et al. . ... 424/258 4,031,098 6… 
2013
2013
Functionalized 9-bromo - camptothecin derivative
The present invention has a cytotoxic activity, cancer, new functionalized 9-bromo useful in the treatment of diseases such as… 
2006
2006
Quinazoline Antifolate Thymidylate Synthase Inhibitor That Is a Potent Inhibitor of LI 210 Tumor Cell Growth in Vitro and in Vivo : A New Agent for Clinical Study 1
AÃ--(5-|Ar-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-/Vmethylamino]-2-thenoyl)-i.-glutamic acid (ICI D1694) is a water… 
2006
2006
Immediate­release therapeutic systems for improved oral absorption of 7-〔（e）-t-butyloxyminomethyl〕 camptothecin
The pharmaceutical composition comprising as an active ingredient is put Kam tote described herein. The emission treatment system… 
1998
1998
Characterization of Human Cellular g-Glutamyl Hydrolase
A previously identified cDNA encoding a human g-glutamyl hydrolase was expressed in a baculovirus system. The expressed protein… 
1986
1986
Synthesis and retention of methotrexate polyglutamates in Ehrlich ascites carcinoma cells.
The formation of methotrexate (MTX) polyglutamates in Ehrlich ascites carcinoma parental and 5-fluorodeoxy-uridine (FdUrd… 
Highly Cited
1984
Highly Cited
1984
Mammalian folyl polyglutamate synthetase: partial purification and properties of the mouse liver enzyme.
Folyl polyglutamate synthetase has been partially purified from mouse liver, and the general features of this enzyme have been… 
1983
1983
Folyl and Antifolyl Polyglutamates
The role of folylpolyglutamates in biosynthetic processes has gained increasing importance with the recognition that these com… 
1983
1983
Thymidylate synthase, dihydrofolate reductase, folyl binder, 10-formyl-H4PteGlu synthetase, 5,10-methenyl-H4PteGlu cyclohydrolase and 5,10-methylene-H4PteGlu dehydrogenase derived from cells of human…
In the past few years we have been engaged in studying several folate cofactor requiring enzymes derived from human cells; namely… 
1979
1979
Structural role of the polyglutamate portion of the folate found in T4D bacteriophage baseplate
Three types of reagents were used to determine the structural role and location of the polyglutamate portion of the Escherichia…