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polyglutamate camptothecin

Known as: Camptothecin Polyglutamate, PG-CPT, Polyglutamate PG-CPT 
A therapeutic formulation consisting of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, conjugated with polyglutamate… 
National Institutes of Health

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CamptothecinPolyglutamic Acid
analogs & derivatives

Papers overview

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1998
1998
Characterization of Human Cellular g-Glutamyl Hydrolase
A previously identified cDNA encoding a human g-glutamyl hydrolase was expressed in a baculovirus system. The expressed protein… 
1996
1996
Enzymatic deconjugation of erythrocyte polyglutamyl folates during preparation for folate assay: investigation with reversed-phase liquid chromatography.
Erythrocyte (RBC) folates occur mainly as 5-methyltetrahydrofolate polyglutamates. Determination of RBC folate concentration… 
1991
1991
Rat liver dimethylglycine dehydrogenase. Flavinylation of the enzyme in hepatocytes in primary culture and characterization of a cDNA clone.
Dimethylglycine dehydrogenase (Me2GlyDH), an enzyme of choline catabolism specifically expressed in the mammalian liver, was… 
1990
1990
Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.
The synthesis and biological evaluation of N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]- benzoyl]-L… 
Highly Cited
1987
Highly Cited
1987
Mammalian folylpoly-gamma-glutamate synthetase. 4. In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis.
The regulation of folate and folate analogue metabolism was studied in vitro by using purified hog liver folylpolyglutamate… 
1985
1985
Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites.
Highly Cited
1984
Highly Cited
1984
Mammalian folyl polyglutamate synthetase: partial purification and properties of the mouse liver enzyme.
Folyl polyglutamate synthetase has been partially purified from mouse liver, and the general features of this enzyme have been… 
1984
1984
Methotrexate analogues--XVII. Antitumor activity of 4-amino-4-deoxy-N10-methylpteroyl-D,L-homocysteic acid and its dual inhibition of dihydrofolate reductase and folyl polyglutamate synthetase.
1983
1983
Folyl and Antifolyl Polyglutamates
The role of folylpolyglutamates in biosynthetic processes has gained increasing importance with the recognition that these com… 
Highly Cited
1969
Highly Cited
1969
The subcellular localization of pteroyl polyglutamate hydrolase and folate in guinea pig intestinal mucosa.
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