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Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).
- B. Teicher, S. Holden, E. Frei
- BiologyCancer research
- 15 January 1987
TLDR
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
- G. Westerhof, J. Schornagel, H. Pinedo
- Biology, ChemistryMolecular pharmacology
- 1 September 1995
TLDR
A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil.
- W. Ensminger, A. Rosowsky, E. Frei
- Medicine, BiologyCancer research
- 1 November 1978
TLDR
Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response.
- L. Ayash, J. Wright, E. Frei
- Medicine, BiologyJournal of clinical oncology : official journal…
- 1 June 1992
TLDR
Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts.
- A. Rosowsky, H. Lazarus, E. Frei
- MedicineBiochemical pharmacology
- 15 February 1980
Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and…
- J. Wright, Chitra M. Vaidya, Y. Chen, A. Rosowsky
- Biology, ChemistryBiochemical pharmacology
- 1 July 2000
Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
- M. Rhee, J. Galivan, J. Wright, A. Rosowsky
- Biology, ChemistryMolecular pharmacology
- 1 April 1994
TLDR
Comparison of pharmacokinetics of 5-fluorouracil and 5-fluorouracil with concurrent thymidine infusions in a Phase I trial.
- J. Kirkwood, W. Ensminger, A. Rosowsky, N. Papathanasopoulos, E. Frei
- Medicine, BiologyCancer research
- 1980
The serum half-life of 5-fluorouracil (5-FUra) in humans is best described as a biexponential decay function, with t1/2 alpha = 7.8 +/- 2.6 (S.E.) min and t1/2 beta = 36.8 +/- 13.5 min during initial…
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
- A. Rosowsky, H. Bader, C. Cucchi, R. Moran, W. Kohler, J. Freisheim
- Chemistry, BiologyJournal of medicinal chemistry
- 1 July 1988
TLDR
Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium…
- A. Rosowsky, H. Fu, D. Chan, S. Queener
- Chemistry, BiologyJournal of medicinal chemistry
- 6 May 2004
Six previously undescribed N-(2,4-diaminopteridin-6-yl)methyldibenz[b,f]azepines with water-solubilizing O-carboxyalkyloxy or O-carboxybenzyloxy side chains at the 2'-position were synthesized and…
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