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- Publications
- Influence
Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).
- B. Teicher, S. Holden, +5 authors E. Frei
- Biology, Medicine
- Cancer research
- 15 January 1987
We have developed a human head and neck squamous cell carcinoma cell line (SCC-25/CP) which is relatively stably resistant to cis-diamminedichloroplatinum(II) (CDDP) after repeated exposure to… Expand
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
- G. Westerhof, J. Schornagel, +7 authors H. Pinedo
- Biology, Medicine
- Molecular pharmacology
- 1 September 1995
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro against human and murine cell lines expressing different levels of the… Expand
A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil.
- W. Ensminger, A. Rosowsky, +5 authors E. Frei
- Medicine
- Cancer research
- 1 November 1978
Abstract We have attempted to evaluate the degree to which hepatic arterial infusion of 5-fluoro-2′-deoxyuridine (FdUrd) or 5-fluorouracil produces higher hepatic and lower systemic drug… Expand
Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response.
- L. Ayash, J. Wright, +7 authors E. Frei
- Medicine
- Journal of clinical oncology : official journal…
- 1 June 1992
BACKGROUND
Cyclophosphamide, which forms the nucleus for virtually all preparative regimens for autologous bone marrow transplantation (ABMT), is an alkylating agent of which cytotoxicity is not… Expand
Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts.
- A. Rosowsky, H. Lazarus, +5 authors E. Frei
- Chemistry, Medicine
- Biochemical pharmacology
- 15 February 1980
Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
- M. Rhee, J. Galivan, J. Wright, A. Rosowsky
- Biology, Medicine
- Molecular pharmacology
- 1 April 1994
Studies on the mode of action of PT523 [N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine], a potent nonpolyglutamatable antifolate, were carried out in sensitive and resistant H35… Expand
Comparison of pharmacokinetics of 5-fluorouracil and 5-fluorouracil with concurrent thymidine infusions in a Phase I trial.
- J. Kirkwood, W. Ensminger, A. Rosowsky, N. Papathanasopoulos, E. Frei
- Medicine
- Cancer research
- 1980
The serum half-life of 5-fluorouracil (5-FUra) in humans is best described as a biexponential decay function, with t1/2 alpha = 7.8 +/- 2.6 (S.E.) min and t1/2 beta = 36.8 +/- 13.5 min during initial… Expand
Synthesis of new 2,4-Diaminopyrido[2,3-d]pyrimidine and 2,4-Diaminopyrrolo[2,3-d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
- A. Rosowsky, Han Chen, H. Fu, S. Queener
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 2 January 2003
A concise new route allowing easy access to five previously unreported 2,4-diamino-6-(substituted benzyl)pyrido[2,3-d]pyrimidines (2a-e) was developed, involving condensation of… Expand
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
- A. Rosowsky, H. Bader, C. Cucchi, R. Morán, W. Kohler, J. Freisheim
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 July 1988
N delta-Acyl derivatives of the potent folylpolyglutamate synthetase (FPGS) inhibitor N alpha-(4-amino-4-deoxypteroyl)-L-ornithine (APA-L-Orn) were synthesized from N… Expand
Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and…
- J. Wright, Chitra M. Vaidya, Y. Chen, A. Rosowsky
- Biology, Medicine
- Biochemical pharmacology
- 1 July 2000
The potent nonpolyglutamatable dihydrofolate reductase inhibitor N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-o rnithine (PT523) and six of its B-ring (5-deaza, 8-deaza, and… Expand