Biomarkers of Nutrition for Development-Folate Review.
A full appreciation of folate's history as a public health issue, its biology, and an overview of available biomarkers and their interpretation across a range of clinical and population-based uses are provided.
Determination of Folate in Cereal-Grain Food Products Using Trienzyme Extraction and Combined Affinity and Reversed-Phase Liquid Chromatography
- C. Pfeiffer, L. Rogers, J. Gregory
- Chemistry
- 17 February 1997
A trienzyme treatment (employing rat plasma folate conjugase, α-amylase, and protease), followed by affinity chromatography and reversed-phase HPLC, was evaluated for quantification of folates in…
Folate metabolism and requirements.
- L. Bailey, J. Gregory
- BiologyJournal of NutriLife
- 1 April 1999
Estimates of folate requirements have been based on intakes associated with maintenance of normal plasma and erythrocyte folate concentrations and functional tests that reflect abnormalities in folate-dependent reactions.
Folate biosynthesis, turnover, and transport in plants.
- A. Hanson, J. Gregory
- Biology, Environmental ScienceAnnual Review of Plant Biology
- 28 April 2011
Much remains to be discovered about folates, particularly in relation to homeostasis, catabolism, membrane transport, and vacuolar storage, which will require both biochemical and -omics research to lead to improved biofortification strategies based on transgenic or conventional approaches.
Chemical and nutritional aspects of folate research: analytical procedures, methods of folate synthesis, stability, and bioavailability of dietary folates.
- J. Gregory
- BiologyAdvances in Food and Nutrition Research
- 1989
The analysis of folate and its metabolic precursors in biological samples.
- E. Quinlivan, A. Hanson, J. Gregory
- BiologyAnalytical Biochemistry
- 15 January 2006
Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement.
- L. Bailey, J. Gregory
- BiologyJournal of NutriLife
- 1 May 1999
The modulation of these metabolic abnormalities by increasing folate intake suggests that folate requirements may be different in affected individuals (T/T) relative to normal (C/C) or heterozygous (C-T) individuals.
Evidence That COG0325 Proteins are involved in PLP Homeostasis.
- Laurence Prunetti, B. El Yacoubi, V. de Crécy-Lagard
- Biology, ChemistryMicrobiology
- 1 April 2016
Comparative genomic, genetic and metabolic analyses suggest that the pleiotropic phenotypes of the Escherichia coli COG0325 (yggS) mutant reflect an imbalance in pyridoxal 5'-phosphate (PLP) homeostasis.
Direct and Functional Biomarkers of Vitamin B6 Status.
- P. Ueland, A. Ulvik, Luisa Rios‐Avila, Ø. Midttun, J. Gregory
- Biology, ChemistryAnnual review of nutrition
- 17 July 2015
Vitamin B6 status is best assessed by using a combination of biomarkers because of the influence of potential confounders, such as inflammation, alkaline phosphatase activity, low serum albumin, renal function, and inorganic phosphate.
Arabidopsis 10-Formyl Tetrahydrofolate Deformylases Are Essential for Photorespiration[W][OA]
- E. Collakova, A. Goyer, Y. Shachar-Hill
- BiologyThe Plant Cell Online
- 1 July 2008
These findings are consistent with the involvement of At4g17360 and At5g47435 proteins in photorespiration, which is to prevent excessive accumulation of 5-formyl THF, a potent inhibitor of the Gly decarboxylase/Ser hydroxymethyltransferase complex.
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