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poly(malic acid)

Known as: poly(beta-malic acid), polymalic acid 
National Institutes of Health

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MalatesPolymers

Papers overview

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2018
2018
Optimal Design of Novel Functionalized Nanoconjugates Based on Polymalic Acid for Efficient Tumor Endocytosis with Enhanced Anticancer Activity.
To overcome the strong negative charge and improve the endocytosis of poly-β-malic acid (PMLA) as a drug carrier, a pH-sensitive… 
2017
2017
Polymalic Acid Tritryptophan Copolymer Interacts with Lipid Membrane Resulting in Membrane Solubilization.
Anionic polymers with membrane permeation functionalities are highly desirable for secure cytoplasmic drug delivery. We have… 
2017
2017
[Complete genome sequencing of polymalic acid-producing strain Aureobasidium pullulans CCTCC M2012223].
Objective To explore the genome sequence of Aureobasidium pullulans CCTCC M2012223, analyze the key genes related to the… 
2016
2016
A novel rhodamine-based fluorescent pH probe for high-throughput screening of high-yield polymalic acid strains from random mutant libraries
Polymalic acid (PMA) is produced from the yeast-like fungus Auerobasidium pullulans, and is a water-soluble biopolymer with many… 
2015
2015
Quantitative Analysis of PMLA Nanoconjugate Components after Backbone Cleavage
Multifunctional polymer nanoconjugates containing multiple components show great promise in cancer therapy, but in most cases… 
2014
2014
[Gene cloning, expression and characterization of malate-CoA ligase in the polymerization pathway of polymalic acid from Aureobasidium pullulans].
OBJECTIVE To clone and characterize the malate-CoA ligase in the polymalic acid biosynthetic pathway from Aureobasidium pullulans… 
2014
2014
Nanoparticles of esterified polymalic acid for controlled anticancer drug release.
Esterification of microbial poly(malic acid) is performed with either ethanol or 1-butanol to obtain polymalate conjugates… 
2013
2013
Abstract A50: Nanobiocojugates of differential imaging and treatment of brain metastatic tumors
Introduction: A significant clinical problem with brain metastatic (BM) tumors is drug delivery and diagnostic imaging to verify… 
2008
2008
Physarum polymalic acid hydrolase: Recombinant expression and enzyme activation.
2004
2004
608 A new multifunctional drug delivery system based on polymalic acid to inhibit angiogenesis and invasion of human gliomas in vitro and in vivo
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