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Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
The transferrin receptor and the targeted delivery of therapeutic agents against cancer.
Nanomedicine therapeutic approaches to overcome cancer drug resistance.
Overexpression of β1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases
Similar to high-grade brain gliomas, the expression of laminin-8 (and lamin in-10) in breast cancer tissue may be a predictive factor for tumor neovascularization and invasion and suggest that laminationin-2, laminine-8, and laminIn-10 are important components of tumor microvessels and may associate with breast tumor progression.
Overexpression of alpha4 chain-containing laminins in human glial tumors identified by gene microarray analysis.
Overexpression of lamininalpha4 chain in GBM and astrocytoma grade II by gene microarray analysis was confirmed by semiquantitive reverse transcription-PCR and immunohistochemistry, and up-regulation of alpha4 chain-containing laminins could be important for the development of glioma-induced neovascularization and glial tumor progression.
Ambiguities in applying traditional Limulus amebocyte lysate tests to quantify endotoxin in nanoparticle formulations.
- M. Dobrovolskaia, B. Neun, J. Clogston, Hui Ding, J. Ljubimova, S. McNeil
- Biology, MedicineNanomedicine
- 8 June 2010
It is reported that nanoparticles often interfere with these traditional endotoxin detection tests and suggested approaches to detect and overcome such interferences are suggested.
Association between laminin‐8 and glial tumor grade, recurrence, and patient survival
One of these laminins, laminin‐8, was found to be present in highly invasive and malignant glioblastoma multiforme (GBM) (Grade 4 astrocytoma); its expression was associated with a decreased time to tumor recurrence, and it was found in vitro to promote invasion of GBM cell lines.
Nanobiopolymer for Direct Targeting and Inhibition of EGFR Expression in Triple Negative Breast Cancer
Treatment of TNBC with a novel nanobioconjugate based on a poly(β-L-malic acid) nanoplatform results in tumor growth arrest by inhibiting EGFR and its downstream signaling intermediate, phosphorylated Akt.
Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
This study demonstrates trans-BBB delivery of tumor-targeted polymer-conjugated checkpoint inhibitors as an effective GBM treatment via activation of both systemic and local privileged brain tumor immune response.
Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly(β-L-Malic Acid)
- R. Patil, J. Portilla-Arias, J. Ljubimova
- Biology, ChemistryInternational journal of molecular sciences
- 17 September 2012
This work aimed to improve DOX delivery and reduce the toxicity by chemical conjugation with a new nanoplatform based on polymalic acid, found stable under physiological conditions and shown to successfully inhibit in vitro cancer cell growth of several invasive breast carcinoma cell lines.