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The Somatic Genomic Landscape of Glioblastoma
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
This study for the first time provided evidence that CD133 positive cancer stem cells display strong capability on tumor's resistance to chemotherapy.
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
Isolation of cancer stem cells from adult glioblastoma multiforme
The identification of tumor stem cells within adult GBM may represent a major step forward in understanding the origin and maintenance of GBM and lead to the identification and testing of new therapeutic targets.
Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model
Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme.
- A. Lai, A. Tran, T. Cloughesy
- MedicineJournal of clinical oncology : official journal…
- 10 January 2011
Comparative subset analysis showed that poor prognosis patients (recursive partitioning analysis class V/VI) may derive an early benefit from the use of first-line BV and TMZ during and after RT showed improved PFS without improved OS compared to the University of California, Los Angeles/KPLA control group.
Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease.
The geometric distribution and increased burden of retinal amyloid pathology in AD, together with the feasibility to noninvasively detect discrete retinalAmyloid deposits in living patients, may lead to a practical approach for large-scale AD diagnosis and monitoring.
Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration.
This Phase I study demonstrated the feasibility, safety, and bioactivity of an autologous peptide-pulsed dendritic cell vaccine for patients with malignant glioma.
Cyr61 Is Overexpressed in Gliomas and Involved in Integrin-Linked Kinase-Mediated Akt and β-Catenin-TCF/Lef Signaling Pathways
It is shown that Cyr61 can enhance tumorigenicity of glioma cells acting through activated integrin-linked kinase (ILK) to stimulate β-catenin-TCF/Lef and Akt signaling pathways.
Vaccination with Tumor Lysate-Pulsed Dendritic Cells Elicits Antigen-Specific, Cytotoxic T-Cells in Patients with Malignant Glioma
- John S. Yu, Gentao Liu, H. Ying, W. Yong, K. Black, C. Wheeler
- Medicine, BiologyCancer Research
- 15 July 2004
This Phase I study demonstrated the feasibility, safety, and bioactivity of an autologous tumor lysate-pulsed DC vaccine for patients with malignant glioma and demonstrates for the first time the ability of an active immunotherapy strategy to generate antigen-specific cytotoxicity in brain tumor patients.