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plumbagin

Known as: 2-methyl-5-hydroxy-1,4-naphthoquinone, 5-hydroxy-2-methyl-1,4-naphthoquinone 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (7)

AnticoagulantsAntinematodal AgentsAntineoplastic Agents, PhytogenicCardiotonic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Perspectives on medicinal properties of plumbagin and its analogs
Plumbagin is one of the simplest plant secondary metabolite of three major phylogenic families viz. Plumbaginaceae, Droseraceae… 
Review
2012
Review
2012
Targeting NADPH oxidases in vascular pharmacology.
Highly Cited
2010
Highly Cited
2010
Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia
J. Neurochem. (2010) 112, 1316–1326. 
Review
2010
Review
2010
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals
Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy medicine and medicine be thy food… 
Highly Cited
2008
Highly Cited
2008
Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer.
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men. Hormone-refractory invasive PCa is the end… 
Highly Cited
2008
Highly Cited
2008
Cytotoxicity Mechanism of Two Naphthoquinones (Menadione and Plumbagin) in Saccharomyces cerevisiae
Background Quinones are compounds extensively used in studies of oxidative stress due to their role in plants as chemicals for… 
Highly Cited
2006
Highly Cited
2006
Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells
This study is the first to investigate the anticancer effect of plumbagin in human breast cancer cells. Plumbagin exhibited cell… 
Highly Cited
2004
Highly Cited
2004
Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes.
Juglone (5-hydroxy-1,4-naphthoquinone) and plumbagin (5-hydroxy-3-methyl-1,4-naphthoquinone) are yellow pigments found in black… 
Highly Cited
1987
Highly Cited
1987
alpha, beta-Dihydroxyisovalerate dehydratase. A superoxide-sensitive enzyme.
Highly Cited
1979
Highly Cited
1979
Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds.
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