Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

pivalyloxymethyl butyrate

Known as: Pivaloyloxymethyl butyrate, Pivaloyloxymethylbutyrate 
An acyloxyalkyl ester prodrug of butyric acid. Pivaloyloxymethylbutyrate inhibits histone deacetylase, resulting in cell differentiation, cell growth… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Histone deacetylase inhibitory prodrugs that are metabolized to butyric acid and formaldehyde possess antineoplastic properties… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
2007
2007
Histone modification has emerged as a promising approach to cancer therapy. We explored the in vivo efficacy of a butyric acid… Expand
2005
2005
A novel butyric acid derivative, pivaloyloxymethyl butyrate, AN-9, was previously shown to be a potent differentiating agent. AN… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Highly Cited
2004
Highly Cited
2004
This multicenter phase II trial evaluated the therapeutic activity and safety profile of pivaloyloxymethyl butyrate (Pivanex, AN… Expand
Review
2002
Review
2002
Pivaloyloxymethyl butyrate (AN-9), an acyloxyalkyl ester prodrug of butyric acid (BA), has demonstrated greater potency than BA… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • table 3
Highly Cited
2002
Highly Cited
2002
The novel prodrug of butyric acid, pivaloyloxymethyl butyrate (AN-9), a histone deacetylase inhibitor, shows great promise as an… Expand
Highly Cited
2001
Highly Cited
2001
The interaction of Adriamycin and pivaloyloxymethyl butyrate (AN-9) was investigated in IMR-32 neuroblastoma and MCF-7 breast… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
2000
2000
Pivalyloxymethyl butyrate (AN9) is an anticancer derivative of butyric acid. In this study, doxorubicin (DXR) and AN9… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
1994
1994
A butyric acid pro‐drug, pivaloyioxymethyl butyrate, AN‐9, developed in our laboratory, was previously shown to act as a… Expand
Highly Cited
1993
Highly Cited
1993
The novel prodrug of butyric acid (BA), pivaloyloxymethyl butyrate, has been shown, in vitro, to induce differentiation and… Expand