pivalyloxymethyl butyrate

Known as: Pivaloyloxymethyl butyrate, Pivaloyloxymethylbutyrate 
An acyloxyalkyl ester prodrug of butyric acid. Pivaloyloxymethylbutyrate inhibits histone deacetylase, resulting in cell differentiation, cell growth… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2016
012319912016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Histone modification has emerged as a promising approach to cancer therapy. We explored the in vivo efficacy of a butyric acid… (More)
Is this relevant?
2004
2004
This multicenter phase II trial evaluated the therapeutic activity and safety profile of pivaloyloxymethyl butyrate (Pivanex, AN… (More)
Is this relevant?
2003
2003
In addition to its action as a topoisomerase II poison, mitoxantrone is activated by formaldehyde to bind DNA, forming DNA… (More)
Is this relevant?
2002
2002
The novel prodrug of butyric acid, pivaloyloxymethyl butyrate (AN-9), a histone deacetylase inhibitor, shows great promise as an… (More)
Is this relevant?
2001
2001
The interaction of Adriamycin and pivaloyloxymethyl butyrate (AN-9) was investigated in IMR-32 neuroblastoma and MCF-7 breast… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
2000
2000
Pivalyloxymethyl butyrate (AN9) is an anticancer derivative of butyric acid. In this study, doxorubicin (DXR) and AN9… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1998
1998
The anti-proliferative effects of pivaloyloxymethyl butyrate (AN-9), a butyric acid (BA) derivative with potent tumor… (More)
  • table 1
  • table 2
  • table 3
  • figure 2
Is this relevant?
1997
1997
A novel butyric acid derivative, pivaloyloxymethyl butyrate, AN-9, was previously shown to be a potent differentiating agent. AN… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
1994
1994
A butyric acid pro-drug, pivaloyloxymethyl butyrate, AN-9, developed in our laboratory, was previously shown to act as a… (More)
Is this relevant?
1993
1993
The novel prodrug of butyric acid (BA), pivaloyloxymethyl butyrate, has been shown, in vitro, to induce differentiation and… (More)
Is this relevant?