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pivalyloxymethyl butyrate

Known as: Pivaloyloxymethyl butyrate, Pivaloyloxymethylbutyrate 
An acyloxyalkyl ester prodrug of butyric acid. Pivaloyloxymethylbutyrate inhibits histone deacetylase, resulting in cell differentiation, cell growth… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (2)

AN-9Pivanex

Broader (1)

Butyrates

Papers overview

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2018
2018
Synergistic Effect of Endogenous and Exogenous Aldehydes on Doxorubicin Toxicity in Yeast
Anthracyclines are frequently used to treat many cancers including triple negative breast cancer, which is commonly observed in… 
2007
2007
Activation of clinically used anthracyclines by the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate
The anthracycline group of compounds is extensively used in current cancer chemotherapy regimens and is classified as… 
2005
2005
Butyric acid and pivaloyloxymethyl butyrate, AN-9, a novel butyric acid derivative, induce apoptosis in HL-60 cells
A novel butyric acid derivative, pivaloyloxymethyl butyrate, AN-9, was previously shown to be a potent differentiating agent. AN… 
2004
2004
Activity of pivaloyloxymethyl butyrate, a novel anticancer agent, on primary human tumor colony-forming units
The anti-proliferative effects of pivaloyloxymethyl butyrate (AN-9), a butyric acid (BA) derivative with potent tumor… 
2004
2004
Formation of mitoxantrone adducts in human tumor cells: potentiation by AN-9 and DNA methylation.
The ability of mitoxantrone to form DNA adducts was investigated in a series of human tumor cell lines consisting of human… 
2003
2003
Mitoxantrone Mediates Demethylation and Re-Expression of Cyclin D2, Estrogen Receptor 14.3.3 Sigma In Breast Cancer Cells
In addition to its action as a topoisomerase II poison, mitoxantrone is activated by formaldehyde to bind DNA, forming DNA… 
2001
2001
Butyrate ( AN-9 ) with the Formaldehyde-releasing Prodrug Pivaloyloxymethyl Molecular Basis for the Synergistic Interaction of Adriamycin Updated
The interaction of Adriamycin and pivaloyloxymethyl butyrate (AN-9) was investigated in IMR-32 neuroblastoma and MCF-7 breast… 
2000
2000
Uptake of pivaloyloxymethyl butyrate into leukemic cells and its intracellular esterase-catalyzed hydrolysis
Abstract Pivaloyloxymethyl butyrate (AN-9), a butyric acid (BA) prodrug, exhibited low toxicity and significant anticancer… 
1996
1996
Esterase inhibitors diminish the modulation of gene expression by butyric acid derivative, pivaloyloxymethyl butyrate (AN-9).
Pivaloyloxymethyl butyrate (AN-9) belongs to the family of acyloxyalkyl ester prodrugs of carboxylic acids which undergo… 
1994
1994
Butyrate-induced differentiation in leukemic myeloid cells - in-vitro and in-vivo studies.
A study of the effects of three differentiating agents, butyric acid, retinoic acid and cytosine arabinoside on proliferation and… 
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