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pivalyloxymethyl butyrate

Known as: Pivaloyloxymethyl butyrate, Pivaloyloxymethylbutyrate 
An acyloxyalkyl ester prodrug of butyric acid. Pivaloyloxymethylbutyrate inhibits histone deacetylase, resulting in cell differentiation, cell growth… Expand
National Institutes of Health

Papers overview

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2008
2008
Histone deacetylase inhibitory prodrugs that are metabolized to butyric acid and formaldehyde possess antineoplastic properties… Expand
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2007
2007
Histone modification has emerged as a promising approach to cancer therapy. We explored the in vivo efficacy of a butyric acid… Expand
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2005
2005
A novel butyric acid derivative, pivaloyloxymethyl butyrate, AN-9, was previously shown to be a potent differentiating agent. AN… Expand
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Highly Cited
2004
Highly Cited
2004
This multicenter phase II trial evaluated the therapeutic activity and safety profile of pivaloyloxymethyl butyrate (Pivanex, AN… Expand
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Review
2002
Review
2002
Pivaloyloxymethyl butyrate (AN-9), an acyloxyalkyl ester prodrug of butyric acid (BA), has demonstrated greater potency than BA… Expand
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2002
2002
The novel prodrug of butyric acid, pivaloyloxymethyl butyrate (AN-9), a histone deacetylase inhibitor, shows great promise as an… Expand
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2001
2001
The interaction of Adriamycin and pivaloyloxymethyl butyrate (AN-9) was investigated in IMR-32 neuroblastoma and MCF-7 breast… Expand
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2000
2000
Pivalyloxymethyl butyrate (AN9) is an anticancer derivative of butyric acid. In this study, doxorubicin (DXR) and AN9… Expand
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1994
1994
A butyric acid pro-drug, pivaloyloxymethyl butyrate, AN-9, developed in our laboratory, was previously shown to act as a… Expand
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1993
1993
The novel prodrug of butyric acid (BA), pivaloyloxymethyl butyrate, has been shown, in vitro, to induce differentiation and… Expand
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