• Corpus ID: 39942401

Esterase inhibitors diminish the modulation of gene expression by butyric acid derivative, pivaloyloxymethyl butyrate (AN-9).

@article{Rabizadeh1996EsteraseID,
  title={Esterase inhibitors diminish the modulation of gene expression by butyric acid derivative, pivaloyloxymethyl butyrate (AN-9).},
  author={Esther Rabizadeh and Matitiahu Shaklai and Lea Eisenbach and Abraham Nudelman and Ada Rephaeli},
  journal={Israel journal of medical sciences},
  year={1996},
  volume={32 12},
  pages={
          1186-91
        }
}
Pivaloyloxymethyl butyrate (AN-9) belongs to the family of acyloxyalkyl ester prodrugs of carboxylic acids which undergo intracellular hydrolysis to yield butyric acid (BA). We have previously shown that AN-9 and BA reduce the level of c-myc and enhance c-jun transcripts in HL-60 cells, and that the differentiation of these cells, induced by AN-9, is dependent on the presence of intracellular esterases. In this study we show that esterase inhibitors abolish the changes induced by AN-9 on c-myc… 

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