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Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death.
TLDR
It is shown that doxorubicin-DNA adducts induce a more cytotoxic response in HL-60 cells than doxorbicin as a single agent, and that theseAdducts are more cytOToxic than topoisomerase II-mediated lesions.
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Factors determining the stability, size distribution, and cellular accumulation of small, monodisperse chitosan nanoparticles as candidate vectors for anticancer drug delivery: application to the…
TLDR
A [14C]-radiolabeled form of the anticancer agent doxorubicin was efficiently encapsulated within the CNP, confirming the feasibility of using this system as a drug delivery vector and suggesting that the nanoparticles are well tolerated and highly suited for biomedical applications.
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The Power and Potential of Doxorubicin‐DNA Adducts
TLDR
The adducts appear to be more cytotoxic than doxorubicin alone, and also less susceptible to drug‐efflux forms of resistance, they offer new approaches to improving the anticancer activity of the anthracyclines.
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Characterization of covalent adriamycin-DNA adducts.
TLDR
It is shown by homo- and heteronuclear NMR spectroscopy that the covalent Adriamycin-DNA adduct is structurally equivalent to that resulting from direct reaction with formaldehyde.
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Solution properties of wheat-flour arabinoxylans and enzymically modified arabinoxylans
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Formation of adriamycin--DNA adducts in vitro.
TLDR
The results are consistent with a two-step reaction mechanism involving reductive activation of adriamycin, with the activated species then reacting with the guanine residues of either dsDNA or ssDNA.
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Interstrand cross-linking by adriamycin in nuclear and mitochondrial DNA of MCF-7 cells.
TLDR
The formation of such high levels of adducts and cross-links could therefore be expected to contribute to the mechanism of action of Adriamycin.
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A Molecular Understanding of Mitoxantrone-DNA Adduct Formation
TLDR
These results account for the enhanced covalent binding of mitoxantrone to methylated CG sequences and provide a molecular model of the interactions.
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Activation of adriamycin by the pH-dependent formaldehyde-releasing prodrug hexamethylenetetramine.
TLDR
HMTA has some potential for localized activation of Adriamycin in solid tumors because it is known to hydrolyze under cellular conditions and release six molecules of formaldehyde in a pH-dependent manner.
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Neutrophil-mediated activation of mitoxantrone to metabolites which form adducts with DNA.
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