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Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death.
TLDR
It is shown that doxorubicin-DNA adducts induce a more cytotoxic response in HL-60 cells than doxorbicin as a single agent, and that theseAdducts are more cytOToxic than topoisomerase II-mediated lesions. Expand
The Power and Potential of Doxorubicin‐DNA Adducts
TLDR
The adducts appear to be more cytotoxic than doxorubicin alone, and also less susceptible to drug‐efflux forms of resistance, they offer new approaches to improving the anticancer activity of the anthracyclines. Expand
The effect of membrane potential on the mammalian sodium‐potassium pump reconstituted into phospholipid vesicles.
TLDR
Measurement of fluorescence changes of the carbocyanine dye DiS‐C3‐(5) showed that the ionophores generated potentials of the expected orientation and of sufficient stability for their effects on active transport to be assessed, demonstrating that values of diffusion potentials calculated from the Nernst or constant‐field equation are accurate. Expand
Butyric acid prodrugs are histone deacetylase inhibitors that show antineoplastic activity and radiosensitizing capacity in the treatment of malignant gliomas
TLDR
The data suggest that novel butyric acid prodrugs provide a promising treatment strategy for malignant gliomas as single agents and in combination with radiation therapy. Expand
Activation of adriamycin by the pH-dependent formaldehyde-releasing prodrug hexamethylenetetramine.
TLDR
HMTA has some potential for localized activation of Adriamycin in solid tumors because it is known to hydrolyze under cellular conditions and release six molecules of formaldehyde in a pH-dependent manner. Expand
In vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas.
TLDR
The data suggest that AN-9 in combination with radiation may be an effective therapy for malignant gliomas. Expand
Regulation of genes coding for enzyme constituents of the bacterial phosphotransferase system.
TLDR
Regulation of the synthesis of the proteins of the phosphoenolpyruvate:sugar phosphotransferase system was systematically studied in wild-type and mutant strains of Salmonella typhimurium and Escherichia coli to suggest a mechanism which depends on cyclic adenosine monophosphate and its receptor protein. Expand
Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation.
TLDR
Analysis of protein kinases with respect to cell cycle progression indicates that ATR is required for G(2)/M checkpoint responses while ATM appears to function in G(1) mediated responses to anthracycline adducts, which may be potential drug targets to achieve synergistic cytotoxic responses to doxorubicin-DNA adduct forming therapies. Expand
Derivatives of butyric acid as potential anti‐neoplastic agents
TLDR
The results suggest that AN‐9 is a potential anti‐neoplastic agent ar well as a tool for investigation of the differentiation induction mechanism. Expand
Kinetic analyses of the sugar phosphate:sugar transphosphorylation reaction catalyzed by the glucose enzyme II complex of the bacterial phosphotransferase system.
TLDR
In vitro kinetic studies of the transphosphorylation reaction catalyzed by the mutant enzyme showed a decrease in maximal velocity and increases in the Km values for both the sugar and sugar phosphate substrates, consistent with the conclusion that a single Enzyme II complex catalyzes both transport and transph phosphorylation of its sugar substrates. Expand
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