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piritrexim

Known as: Pyrido(2,3-d)pyrimidine-2,4-diamine, 6-((2,5-dimethoxyphenyl)methyl)-5-methyl-, 6-((2,5-Dimethoxyphenyl)methyl)-5-methylpyrido(2,3-d)pyrimidine-2,4-diamine, 2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine 
A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

Antineoplastic AgentsFolic Acid AntagonistsPyrimidines

Narrower (2)

BW 301UPiritrexim Isethionate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines
., single compound able to interact with multiple altered pathogenetic pathways, for the multifactorial mechanistic nature of… 
2009
2009
Synthesis of Functionalized Diaryl Alkanes from Azines.
such as trimethoprim, papaverin and piritrexim. The usual method for the synthesis of this class of compounds include (i… 
2005
2005
P-glycoprotein confers methotrexate resistance in 3 T 6 cells with deficient carrier-mediated methotrexate uptake ( multidrug resistance / MDRl gene / methotrexate / membrane transport / retroviral…
P-glycoprotein (Pgp), a transmembrane efflux pump encoded by the MDR] gene, transports various lipophilic drugs that enter the… 
Review
1996
Review
1996
Chemotherapy for advanced bladder cancer.
For the past 10 years, chemotherapy for advanced urothelial carcinoma has centered on cisplatin-based combination regimens such… 
Review
1995
Review
1995
Treatment of psoriasis with cytotoxic drugs
This review is an update on the use of cytotoxic drugs for psoriasis. Drugs reviewed include methotrexate, 6-thioguanine… 
1993
1993
Case report of acquired piritrexim resistance and collateral methotrexate sensitivity in recurrent squamous cell carcinoma of the head and neck.
1992
1992
A pilot study of piritrexim in mycosis fungoides.
To the Editor.— Piritrexim (2,4-diamino-6[2,5-dimeth-oxybenzyl]-5-methylpyrido-[2,3-D] pyrimidine) (PTX) (BW-301U) is a novel… 
1991
1991
Systemic drug therapy for psoriasis. The most critical issues.
Guzzo and colleagues 1 present, in this issue ofArchives, the results of a phase I and II study of piritrexim, a nonclassical… 
1987
1987
Phase II trial of oral piritrexim (BW301U) in patients with stage III non-small cell lung cancer.
Administration a la dose de 160 mg/m 2 deux fois par jour pendant 5 jours. Etude chez 35 malades. Effet «marginal» du piritrexim 
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