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piritrexim

Known as: Pyrido(2,3-d)pyrimidine-2,4-diamine, 6-((2,5-dimethoxyphenyl)methyl)-5-methyl-, 6-((2,5-Dimethoxyphenyl)methyl)-5-methylpyrido(2,3-d)pyrimidine-2,4-diamine, 2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine 
A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

Antineoplastic AgentsFolic Acid AntagonistsPyrimidines

Narrower (2)

BW 301UPiritrexim Isethionate

Papers overview

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2005
2005
P-glycoprotein confers methotrexate resistance in 3 T 6 cells with deficient carrier-mediated methotrexate uptake ( multidrug resistance / MDRl gene / methotrexate / membrane transport / retroviral…
P-glycoprotein (Pgp), a transmembrane efflux pump encoded by the MDR] gene, transports various lipophilic drugs that enter the… 
Review
1995
Review
1995
Treatment of psoriasis with cytotoxic drugs
This review is an update on the use of cytotoxic drugs for psoriasis. Drugs reviewed include methotrexate, 6-thioguanine… 
1992
1992
A pilot study of piritrexim in mycosis fungoides.
To the Editor.— Piritrexim (2,4-diamino-6[2,5-dimeth-oxybenzyl]-5-methylpyrido-[2,3-D] pyrimidine) (PTX) (BW-301U) is a novel… 
1991
1991
Systemic drug therapy for psoriasis. The most critical issues.
Guzzo and colleagues 1 present, in this issue ofArchives, the results of a phase I and II study of piritrexim, a nonclassical…