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pimobendan

Known as: 4,5-dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazole-5-yl)-5-methyl-3(2H)-pyridazinone, pimobendane 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (4)

Cardiotonic AgentsPhosphodiesterase InhibitorsPyridazinesVasodilator Agents

Narrower (2)

UD CG 115Vetmedin
pimobendan 10 MG Chewable Tablet [Vetmedin]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Positive inotropic effect of purified green tea catechin derivative in guinea pig hearts: the measurements of cellular Ca2+ and nitric oxide release.
Review
2003
Review
2003
Role of nonglycosidic inotropic agents: indications, ethics, and limitations.
1999
1999
Effects of Pimobendan on the L-Type Ca2+ Current and Developed Tension in Guinea-Pig Ventricular Myocytes and Papillary Muscle: Comparison with IBMX, Milrinone, and Cilostazol
Summary. In this study, we compared the effects of pimobenda (PIM), a putative Ca2+-sensitizer and phosphodiesterase (PDE… 
1998
1998
The Novel Insulinotropic Mechanism of Pimobendan: Direct Enhancement of the Exocytotic Process of Insulin Secretory Granules by Increased Ca2+ Sensitivity inβ -Cells.
Pimobendan is a new class of inotropic drug that augments Ca2+ sensitivity and inhibits phosphodiesterase (PDE) activity in… 
1996
1996
Comparison of the effects of levosimendan, pimobendan, and milrinone on canine left ventricular-arterial coupling and mechanical efficiency
We examined and compared the effects of levosimendan, a new myofilament calcium sensitizer with phosphodiesterase inhibiting… 
1991
1991
A model for human cardiac troponin C and for modulation of its Ca2+ affinity by drugs
Calcium sensitizers are drugs which increase force development in striated muscle by sensitizing myofilaments to Ca2+. This can… 
1991
1991
Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle…
SummaryThe present study was performed to compare the effects of the new positive inotropic phosphodiesterase III inhibitors… 
1989
1989
The Positive Inotropic Effect of Pimobendan Involves Stereospecific Increases in the Calcium Sensitivity of Cardiac Myofilaments
We have studied the effect of pimobendan (UD-CG 1 15 BS) on the electrical, mechanical, and biochemical activity of intact and… 
1989
1989
Pimobendan Increases Survival of Cardiomyopathic Hamsters
Summary: We investigated the effect of the new cardiotonic drug pimobendan on survival of hereditary cardiomyopathic hamsters… 
1989
1989
Effects of pimobendan, a novel inotropic agent, on intracellular calcium and tension in isolated ferret ventricular muscle.
1. In this study we have investigated the effects of a novel inotropic agent, pimobendan (UDCG 115-BS), on skinned and intact… 
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