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picrotoxinin

Known as: (1aR-(1a alpha,2a beta,3 beta,6 beta,6a beta,8aS*,8b beta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxa cyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, picrotoxinine 
 
National Institutes of Health

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3 relations

Broader (2)

GABA-A Receptor AntagonistsPicrotoxin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Three TAS2R Bitter Taste Receptors Mediate the Psychophysical Responses to Bitter Compounds of Hops (Humulus lupulus L.) and Beer
In order to study the role of different haplotypes of taste receptor genes in food choice, it is necessary to first identify the… Expand
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Highly Cited
2005
Highly Cited
2005
Modulation of the activity of pyramidal neurons in rat prefrontal cortex by raphe stimulation in vivo: involvement of serotonin and GABA.
Serotonin is involved in psychiatric disorders exhibiting abnormal prefrontal cortex (PFC) function (e.g. major depression… Expand
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Highly Cited
2001
Highly Cited
2001
Control of Dorsal Raphe Serotonergic Neurons by the Medial Prefrontal Cortex: Involvement of Serotonin-1A, GABAA, and Glutamate Receptors
Anatomical evidence indicates that medial prefrontal cortex (mPFC) neurons project to the dorsal raphe nucleus (DR). In this… Expand
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Highly Cited
2001
Highly Cited
2001
Control of Serotonergic Function in Medial Prefrontal Cortex by Serotonin-2A Receptors through a Glutamate-Dependent Mechanism
We examined the in vivo effects of the hallucinogen 4-iodo-2,5-dimethoxyamphetamine (DOI). DOI suppressed the firing rate of 7 of… Expand
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Highly Cited
2000
Highly Cited
2000
GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans.
1. We report the cloning and expression of a novel Caenorhabditis elegans polypeptide, GLC-3, with high sequence identity to… Expand
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Highly Cited
1995
Highly Cited
1995
Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block.
Ionotropic receptors for gamma-aminobutyric acid (GABA) are important to inhibitory neurotransmission in the mammalian retina… Expand
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Highly Cited
1994
Highly Cited
1994
N-containing sugars from Morus alba and their glycosidase inhibitory activities.
The reexamination of N-containing sugars from the roots of Morus alba by improved purification procedures led to the isolation of… Expand
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Highly Cited
1993
Highly Cited
1993
A point mutation in a Drosophila GABA receptor confers insecticide resistance
VERTEBRATES and invertebrates both have GABA (γ-aminobutyric acid) as a major inhibitory neurotransmitter1,2. GABAA receptors in… Expand
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Highly Cited
1992
Highly Cited
1992
The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.
Purified preparations of the inhibitory glycine receptor (GlyR) contain alpha and beta subunits, which share homologous primary… Expand
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Highly Cited
1984
Highly Cited
1984
Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex.
The interactions of pentamethylenetetrazole and ten tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA… Expand
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