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picrotoxinin

Known as: (1aR-(1a alpha,2a beta,3 beta,6 beta,6a beta,8aS*,8b beta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxa cyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, picrotoxinine 
National Institutes of Health

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3 relations

Broader (2)

GABA-A Receptor AntagonistsPicrotoxin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Changes in extracellular adenosine levels and population spike amplitude during graded hypoxia in the rat hippocampal slice
SummaryConcentrations of adenosine and inosine in the incubation media of baths containing rat hippocampal slices were measured… 
2002
2002
Unique insecticide specificity of human homomeric rho 1 GABA(C) receptor.
Several convulsants and major insecticides block the gamma-aminobutyric acid (GABA)-gated chloride channel in brain on binding to… 
1998
1998
Cytotoxic action of lindane in neocortical GABAergic neurons is primarily mediated by interaction with flunitrazepam‐sensitive GABAA receptors
The cytotoxic action of the γ‐isomer of hexachlorocyclohexane (γ‐HCH; lindane) was studied in cultured mouse neocortical neurons… 
1993
1993
CoMFA validation of the superposition of six classes of compounds which block GABA receptors non-competitively
SummaryThirty-six compounds, representing six different structural classes of insecticides which are known to act at the… 
1993
1993
Lindane Administration to the Rat Induces Modifications in the Regional Cerebral Binding of [3H]Muscimol, [3H]‐Flunitrazepam, and t‐[35S]Butylbicyclophosphorothionate: An Autoradiographic Study
Abstract: The effect of lindane administration on the specific binding of ligands to different sites on the GABAA receptor… 
1992
1992
Structure of RG-12561 dichloromethane solvate and a diastereomer.
(III): [4 alpha,6 beta(E)]-(+-)-6-(2-[2-(4-Fluoro-3-methylphenyl)- 4,4,6,6-tetramethyl-1-cyclohexen-1-yl]ethenyl)-4… 
1991
1991
Development of a mechanism of action-based screen for anthelmintic microbial metabolites with avermectinlike activity and isolation of milbemycin-producing Streptomyces strains
A high-volume screen for anthelmintic microbial metabolites with an avermectinlike mode of action was developed. The primary… 
1989
1989
The role of GABAA receptor function in peristaltic activity of the guinea‐pig ileum: a comparative study with bicuculline, SR 95531 and picrotoxinin
1 The peristaltic activity of the guinea‐pig ileum was studied in the absence and in the presence of the blockade of GABAA… 
1986
1986
The gamma-aminobutyrate/benzodiazepine receptor from pig brain. Enhancement of gamma-aminobutyrate-receptor binding by the anaesthetic propanidid.
The binding of [3H]muscimol, a gamma-aminobutyrate (GABA) receptor agonist, to a membrane preparation from pig cerebral cortex… 
1985
1985
The Picrotoxinin Binding Site and Its Relationship to the GABA Receptor Complex
Abstract: The binding characteristics of [3H]α‐dihydropicrotoxinin to the picrotoxinin binding site were investigated in membrane… 
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