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Picrotoxin

Known as: picrotoxins, 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8, 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1) 
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore… 
National Institutes of Health

Related topics

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21 relations

Broader (7)

AnalepticsAntidoteCentral Nervous System StimulantsConvulsants
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (7)

Vertigoheelcoriamyrtinedihydropicrotoxininhyenanchin

Papers overview

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2012
2012
Strategy of directly employing paclitaxel to construct vesicles.
A class of aza-arm modified β-cyclodextrins were found to be able to trap paclitaxel (PTX), an effective but strongly hydrophobic… 
2002
2002
A Model for the PTX Properties of H2O-NaCl
In many geologic environments, fluids have compositions that are approximated by the H 2 O-NaCl system. When minerals grow in the… 
1992
1992
Elevation of serum erythropoietin after subtotal parathyroidectomy in chronic haemodialysis patients.
After successful subtotal parathyroidectomy (PTX) in 10 chronic haemodialysis patients, significant elevation of Epo was observed… 
1990
1990
Solid-state structures of (R sub 3 P) sub 2 PtX sub 2 complexes as determined by a combination of sup 13 C( sup 1 H) and sup 31 P( sup 1 H) NMR spectroscopy
Cross-polarization, combined with magic-angle spinning, has been employed to obtain high-resolution solid-state {sup 13}C and… 
1986
1986
Effects of hypercalcemia and parathyroid hormone on blood pressure in normal and renal-failure rats.
Hypertension is common in primary hyperparathyroidism, but the mechanisms are not clear. Significant hypercalcemia induces… 
1984
1984
Evidence for the role of PO4 deficiency in antihypertensive action of a high-Ca diet.
Previous studies indicated a salutary effect of a high-Ca diet on high blood pressure (BP). The mechanism, however, is obscure… 
1982
1982
Parathyroidectomy significantly decreases hypertension in spontaneously hypertensive and deoxycorticosterone plus saline treated rats.
In male Sprague--Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1… 
1982
1982
Palytoxin both induces and inhibits the release of histamine from rat mast cells.
Palytoxin (PTX) is a potent releaser of histamine from rat mast cells. The concentration response curve is bell-shaped with its… 
1980
1980
Calcitonin stimulation of urine flow and sodium excretion in the starling.
Renal effects of synthetic salmon calcitonin (CT) were examined in normal and parathyroidectomized (PTX) starlings, Sturnus… 
1970
1970
The ultimobranchial body in rana pipiens. XI. Response to increased dietary calcium--evidence of possible physiological function.
Ultimobranchialectomy (UBX), and presumably removal of calcitonin, was performed on adult male Rana pipens. Frogs held in tap…