Skip to search formSkip to main contentSkip to account menu

Picrotoxin

Known as: picrotoxins, 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8, 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1) 
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore… 
National Institutes of Health

Related topics

Related topics

21 relations

Broader (7)

AnalepticsAntidoteCentral Nervous System StimulantsConvulsants
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (7)

Vertigoheelcoriamyrtinedihydropicrotoxininhyenanchin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells.
Highly Cited
2008
Highly Cited
2008
Drug delivery with carbon nanotubes for in vivo cancer treatment.
Chemically functionalized single-walled carbon nanotubes (SWNT) have shown promise in tumor-targeted accumulation in mice and… 
Review
2008
Review
2008
Neural mechanism underlying acupuncture analgesia
Review
2007
Review
2007
GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.
Developing networks follow common rules to shift from silent cells to coactive networks that operate via thousands of synapses… 
Highly Cited
2007
Highly Cited
2007
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice
Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by persistent intrusive thoughts (obsessions… 
Highly Cited
2005
Highly Cited
2005
Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28.
PURPOSE The primary aim of National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 was to determine whether four cycles… 
Highly Cited
2004
Highly Cited
2004
The use of a plus-maze to measure anxiety in the mouse
To investigate whether an elevated plus-maze consisting of two open and two closed arms could be used as a model of anxiety in… 
Highly Cited
2000
Highly Cited
2000
Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial.
BACKGROUND & AIMS An earlier pilot study from our liver unit suggested benefit from treatment with pentoxifylline (PTX), an… 
Highly Cited
1986
Highly Cited
1986
Hippocampal sharp waves: Their origin and significance
Highly Cited
1971
Highly Cited
1971
Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)