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Picrotoxin

Known as: picrotoxins, 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8, 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1) 
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore… 
National Institutes of Health

Related topics

Related topics

21 relations

Broader (7)

AnalepticsAntidoteCentral Nervous System StimulantsConvulsants
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (7)

Vertigoheelcoriamyrtinedihydropicrotoxininhyenanchin

Papers overview

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Highly Cited
2007
Highly Cited
2007
pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel.
Highly Cited
2001
Highly Cited
2001
HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling.
Human immunodeficiency virus type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry. It was recently… 
Highly Cited
1992
Highly Cited
1992
GTP‐binding protein involvement in membrane currents evoked by carbachol and histamine in guinea‐pig ileal muscle.
1. Single smooth muscle cells obtained by enzymic dispersion of the longitudinal muscle layer of guinea‐pig ileum were used for… 
Highly Cited
1989
Highly Cited
1989
Release pattern of endogenous dopamine in teleost retinae during light adaptation and pharmacological stimulation
Highly Cited
1984
Highly Cited
1984
The effects of GABA and benzodiazepine receptor antagonists on the anti-conflict actions of diazepam or ethanol
Highly Cited
1984
Highly Cited
1984
A possible correlate of the postsynaptic condition for long-lasting potentiation in the guinea pig hippocampus in vitro
Highly Cited
1981
Highly Cited
1981
Disinhibitory action of acetylcholine in the rat's hippocampus: Extracellular observations
Highly Cited
1980
Highly Cited
1980
Electrophysiological interactions of enkephalins with neuronal circuitry in the rat hippocampus. I. Effects on pyramidal cell activity
Highly Cited
1978
Highly Cited
1978
The striatal dopaminergic function is mediated by the inhibition of a nigral, non-dopaminergic neuronal system via a strio-nigral GABAergic pathway.
Highly Cited
1978
Highly Cited
1978
Benzodiazepine receptors: labeling in intact animals with [3H] flunitrazepam.
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