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Picrotoxin

Known as: picrotoxins, 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8, 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1) 
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore… 
National Institutes of Health

Related topics

Related topics

21 relations

Broader (7)

AnalepticsAntidoteCentral Nervous System StimulantsConvulsants
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (7)

Vertigoheelcoriamyrtinedihydropicrotoxininhyenanchin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus
The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and… 
Highly Cited
2011
Highly Cited
2011
Principles of activation and permeation in an anion-selective Cys-loop receptor
Fast inhibitory neurotransmission is essential for nervous system function and is mediated by binding of inhibitory… 
Highly Cited
2009
Highly Cited
2009
Coadministration of Paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells.
Development of multidrug resistance (MDR) against a variety of conventional and novel chemotherapeutic agents is a significant… 
Highly Cited
2003
Highly Cited
2003
Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways.
Highly Cited
1999
Highly Cited
1999
Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells.
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite abundantly stored in platelets and released upon platelet… 
Highly Cited
1997
Highly Cited
1997
A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons.
The mesencephalic dopaminergic (mesDA) system regulates behavior and movement control and has been implicated in psychiatric and… 
Highly Cited
1985
Highly Cited
1985
GABAB-receptor-activated K+ current in voltage-clamped CA3 pyramidal cells in hippocampal cultures.
GABAB receptors are a subclass of receptors for gamma-amino-n-butyric acid (GABA) that are also activated by the antispastic drug… 
Highly Cited
1985
Highly Cited
1985
Stimulation by central command of locomotion, respiration and circulation during exercise.
Highly Cited
1979
Highly Cited
1979
Paradoxical GABA excitation of nigral dopaminergic cells: indirect mediation through reticulata inhibitory neurons.
Highly Cited
1969
Highly Cited
1969
A study of the action of picrotoxin on the inhibitory neuromuscular junction of the crayfish
1. The effect of picrotoxin on the neuromuscular junction of the crayfish (Cambarus clarkii) was investigated. The potential… 
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