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Picrotoxin

Known as: picrotoxins, 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8, 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1) 
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore… 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Chemically functionalized single-walled carbon nanotubes (SWNT) have shown promise in tumor-targeted accumulation in mice and… 
Review
2008
Review
2008
  • Zhi-qi Zhao
  • Progress in Neurobiology
  • 2008
  • Corpus ID: 12354706
Highly Cited
2008
Highly Cited
2008
Chemically functionalized single-walled carbon nanotubes (SWNTs) have shown promise in tumor targeted accumulation in mice and… 
Review
2007
Review
2007
Developing networks follow common rules to shift from silent cells to coactive networks that operate via thousands of synapses… 
Highly Cited
2005
Highly Cited
2005
PURPOSE The primary aim of National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 was to determine whether four cycles… 
Highly Cited
2004
Highly Cited
2004
  • R. Lister
  • Psychopharmacology
  • 2004
  • Corpus ID: 3329866
To investigate whether an elevated plus-maze consisting of two open and two closed arms could be used as a model of anxiety in… 
Highly Cited
2000
Highly Cited
2000
BACKGROUND & AIMS An earlier pilot study from our liver unit suggested benefit from treatment with pentoxifylline (PTX), an… 
Highly Cited
1986
Highly Cited
1986