G. Johnston

Publications439
h-index75
Citations21,695
Highly Influential Citations408
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THE ‘ABC’ OF GABA RECEPTORS: A BRIEF REVIEW
1. In the mammalian central nervous system, GABA is the main inhibitory neurotransmitter. GABA is a highly flexible molecule and, thus, can exist in many low‐energy conformations. Conformationally… Expand
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GABA(A) receptor channel pharmacology.
  • G. Johnston
  • Biology, Medicine
  • Current pharmaceutical design
  • 31 May 2005
GABA(A) receptor channels are ubiquitous in the mammalian central nervous system mediating fast inhibitory neurotransmission by becoming permeant to chloride ions in response to GABA. The emphasis of… Expand
  • 266
  • 19
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GABAc receptors: relatively simple transmitter -gated ion channels?
  • G. Johnston
  • Chemistry, Medicine
  • Trends in pharmacological sciences
  • 1 September 1996
The inhibitory neurotransmitter, GABA, activates a variety of receptors in all areas of the CNS. Two major subtypes of GABA receptors are well known: (1) GABAA receptors are ligand-gated Cl- channels… Expand
  • 250
  • 16
  • PDF
Amino acid transmitters in the mammalian central nervous system.
2. Evidence for A m i n o Acids as T ransmi t t e r s . . . . . . . . . . . . . . . . . . . . 99 2.1. Synthesis and Storage . . . . . . . . . . . . . . . . . . . . . . . . . . . 100 2.2. Synapt ic… Expand
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GABAA receptor pharmacology.
  • G. Johnston
  • Chemistry, Medicine
  • Pharmacology & therapeutics
  • 1996
gamma-Aminobutyric acid (GABA)A receptors for the inhibitory neurotransmitter GABA are likely to be found on most, if not all, neurons in the brain and spinal cord. They appear to be the most… Expand
  • 295
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Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat.
Summary (1) A study has been made of the effects of bicuculline, a phthalide isoquinoline convulsant alkaloid, on the inhibition of spinal neurones by amino acids and the synaptic inhibition of… Expand
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THE STRUCTURAL SPECIFICITY OF THE HIGH AFFINITY UPTAKE OF l‐GLUTAMATE AND l‐ASPARTATE BY RAT BRAIN SLICES
Abstract— The high affinity uptake system for l‐glutamate and l‐aspartate in rat cerebral cortex may not be specific for these likely excitatory synaptic transmitters, as… Expand
  • 676
  • 9
Effects of a naturally occurring neurosteroid on GABAA IPSCs during development in rat hippocampal or cerebellar slices
1 The effects of the naturally occurring neurosteroid tetrahydrodeoxycorticosterone (THDOC) on GABAA receptor‐mediated miniature, spontaneous and evoked IPSCs was tested using patch‐clamp techniques… Expand
  • 113
  • 8
Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions.
Zinc ions (Zn2+) are stored in synaptic vesicles with glutamate in a number of regions of the brain. When released into the synapse, Zn2+ modulates the activity of various receptors and ion channels.… Expand
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(+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors.
(+)-Borneol is a bicyclic monoterpene used for analgesia and anaesthesia in traditional Chinese and Japanese medicine and is found in the essential oils of medicinal herbs, such as valerian.… Expand
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