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Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons
TLDR
Molecular, electrophysiological and pharmacological studies reported here suggest that a splice variant of the Kv3.4 subunit coassembly enhances the spike repolarizing efficiency of the channels, thereby reducing spike duration and enabling higher repetitive spike rates. Expand
Effects of the neuroprotective agent riluzole on the high voltage-activated calcium channels of rat dorsal root ganglion neurons.
TLDR
Riluzole inhibition of N- and P/Q-type calcium channels may result in reduced calcium influx at presynaptic terminals, which thereby decreases excessive excitatory neurotransmitter release, especially glutamate, a mechanism known to cause neuronal death in ischemic conditions. Expand
Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.
TLDR
One of the mechanisms by which riluzole exerts its neuroprotective action is to preferentially block the inactivated sodium channel of damaged or depolarized neurons under ischemic conditions, thereby suppressing excess stimulation of the glutamatergic receptors and massive influx of Ca++. Expand
Effects of Halothane and Propofol on Excitatory and Inhibitory Synaptic Transmission in Rat Cortical Neurons
TLDR
The prolongation of mIPSCs and IPSCs by halothane and propofol coupled with the ineffectiveness on mEPSCs and EPSCs suggests a selective postsynaptic modulation of GABAA receptors, and the additional calcium-dependent inhibition of m IPSC and m EPSC frequency by Halothane suggests a more general mechanism by this anesthetic on presynaptic transmitter release. Expand
Fipronil Is a Potent Open Channel Blocker of Glutamate-Activated Chloride Channels in Cockroach Neurons
TLDR
GluCls are a critical target for fipronil, especially for the selective toxicity between mammals and insects, and that fipronsil block of GLUCls may play a role in the lack of the cross-resistance with dieldrin. Expand
Vasopressin stimulates action potential firing by protein kinase C-dependent inhibition of KCNQ5 in A7r5 rat aortic smooth muscle cells.
TLDR
The results suggest that the stimulation of Ca(2+) spiking by physiological concentrations of AVP involves PKC-dependent inhibition of KCNQ5 channels and increased AP firing in A7r5 cells. Expand
Potent modulation of neuronal nicotinic acetylcholine receptor-channel by ethanol
TLDR
It is found that ethanol potently modulates the neuronal nicotinic acetylcholine receptor-channel at micromolar concentrations with an EC50 of 88.5 microM, which is significantly lower than most values previously reported for other ion channels. Expand
Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma cells.
TLDR
DPH blocks Na channels both by increasing the fraction of channels in an inactivated state and by delaying the transition from inactivated to closed but available channels, which is enhanced by depolarizing membrane potential and increasing the frequency of stimulation. Expand
Modulation of aminopyridine block of potassium currents in squid axon.
TLDR
The results suggest that aminopyridines enter and occlude K channels, and that the availability of the binding site may be modulated by channel gating such that access is limited by the probability of the channel reaching an intermediate closed state at the resting potential. Expand
Voltage-dependent calcium block of normal and tetramethrin-modified single sodium channels.
TLDR
The results suggest that the Ca-induced decrease of the macroscopic sodium current results from a reduced single sodium channel conductance. Expand
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