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Differential properties of tetrodotoxin-sensitive and tetrodotoxin- resistant sodium channels in rat dorsal root ganglion neurons
  • ML Roy, T. Narahashi
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 1 June 1992
TTX-sensitive (TTX-S) and TTX-resistant (TTX-R) sodium channel currents were analyzed in acutely dissociated dorsal root ganglion (DRG) neurons isolated from 3–12-d-old and adult rats. Currents wereExpand
  • 496
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Differential mechanism of action of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.
Rat dorsal root ganglion neurons are endowed with tetrodotoxin-sensitive(TTX-S) and tetrodotoxin-resistant (TTX-R) sodium channels. The pyrethroid insecticides, which are known to keep sodiumExpand
  • 162
  • 19
Neuroreceptors and ion channels as the basis for drug action: past, present, and future.
  • T. Narahashi
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 July 2000
This article summarizes the development of cellular neuropharmacology and neurotoxicology, based primarily on my own research. The progress of this field depends at least in part on the theoreticalExpand
  • 212
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Neuronal ion channels as the target sites of insecticides.
  • T. Narahashi
  • Chemistry, Medicine
  • Pharmacology & toxicology
  • 1 July 1996
Certain types of neuronal ions channels have been demonstrated to be the major target sites of insecticides. The insecticide-channel interactions that have been studied most extensively areExpand
  • 374
  • 15
Chemicals as tools in the study of excitable membranes.
  • T. Narahashi
  • Physics, Medicine
  • Physiological reviews
  • 1 October 1974
  • 751
  • 10
Ion channels as targets for insecticides.
Most insecticides are neurotoxicants causing various forms of hyperexcitation and paralysis in animals. A variety of neuroreceptors and ion channels have been identified as the major target sites ofExpand
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Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons
Previous studies suggested that tetrodotoxin, a poison from the puffer fish, blocks conduction of nerve and muscle through its rather selective inhibition of the sodium-carrying mechanism. In orderExpand
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Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification.
Alpha-thujone is the toxic agent in absinthe, a liqueur popular in the 19th and early 20th centuries that has adverse health effects. It is also the active ingredient of wormwood oil and some otherExpand
  • 270
  • 8
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Modulation of sodium channels of rat cerebellar Purkinje neurons by the pyrethroid tetramethrin.
The pyrethroid insecticides are known to slow the kinetics of the activation and inactivation gates of sodium channels. This results in prolonged openings of individual sodium channels and prolongedExpand
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Effects of the neuroprotective agent riluzole on the high voltage-activated calcium channels of rat dorsal root ganglion neurons.
The effects of riluzole, a neuroprotective drug, on high voltage-activated (HVA) calcium channels of rat dorsal root ganglion neurons were studied using the whole-cell patch-clamp technique. RiluzoleExpand
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