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piclamilast

Known as: 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide, Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-, 3-cyclopentyloxy-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

BenzamidesPhosphodiesterase 4 InhibitorsPyridines

Narrower (1)

RP 73401

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Phosphodiesterase 4 inhibitor and phosphodiesterase 5 inhibitor combination therapy has antifibrotic and anti‐inflammatory effects in mdx mice with Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is the most common inherited muscular dystrophy. Patients experience DMD in their 20s from… 
2017
2017
University of Groningen Inhibition of phosphodiesterase 4 modulates cytokine induction from toll like receptor activated , but not rhinovirus infected , primary human airway smooth muscle
Background: Virus-induced exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a significant health burden and occur… 
2017
2017
Discovery of tetrahydro-ß-carboline derivatives as a new class of phosphodiesterase 4 inhibitors
Phosphodiesterase 4 is the primary enzyme responsible for degradation of the second messenger cAMP in many of the cells releasing… 
2013
2013
Anti-inflammatory effects of selected drugs on activated neonatal and adult neutrophils
Abstract Aim. In view of the central role of granulocytic neutrophils in the context of inflammatory reactions, the present study… 
2012
2012
Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H2O2 via mechanisms involving AP-1 activation
Abstract Aims. Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases such as chronic… 
2011
2011
Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness.
Neglected tropical disease drug discovery requires application of pragmatic and efficient methods for development of new… 
2006
2006
Inhibition of phosphodiesterase activity, airway inflammation and hyperresponsiveness by PDE4 inhibitor and glucocorticoid in a murine model of allergic asthma.
2006
2006
Synthetic Technology Improvement of Piclamilast
With isovanillin as the starting material,piclamilast,an inhibitor of phosphodiesterase Ⅳ,is synthesized via O-alkylation… 
2003
2003
[Comparison of piclamilast with ciclamilast in bronchodilating and antiallergic effects].
OBJECTIVE To compare the bronchofilating and antiallergic effects with piclamilast with ciclamilast, the second-generation… 
1999
1999
Suppression of anti-CD3-induced interleukin-4 and interleukin-5 release from splenocytes of Mesocestoides corti-infected BALB/c mice by phosphodiesterase 4 inhibitors.
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