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Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke
Background Cigarette smoking contributes to lung remodelling in chronic obstructive pulmonary disease (COPD). As part of remodelling, peribronchiolar fibrosis is observed in the small airways of… Expand
Characterization of Aclidinium Bromide, a Novel Inhaled Muscarinic Antagonist, with Long Duration of Action and a Favorable Pharmacological Profile
- A. Gavaldá, M. Miralpeix, +13 authors J. Beleta
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 November 2009
Aclidinium bromide is a novel potent, long-acting inhaled muscarinic antagonist in development for the treatment of chronic obstructive pulmonary disease. Aclidinium showed subnanomolar affinity for… Expand
Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition
Background Idiopathic pulmonary fibrosis (IPF) is characterised by the aberrant epithelial to mesenchymal transition (EMT) and myofibroblast accumulation. Sphingosine-1-phosphate (S1P) and… Expand
Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells
Background: A common pathological feature of chronic inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) is mucus hypersecretion. MUC5AC is the predominant… Expand
PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression.
Phosphodiesterase 4 (PDE4) is a major cyclic AMP-hydrolyzing enzyme in inflammatory and immunomodulatory cells. The wide range of inflammatory mechanisms under control by PDE4 points to this… Expand
Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways
Mucus hypersecretion and mucin MUC5AC overexpression are pathological features of chronic obstructive pulmonary disease (COPD). This study examines the inhibitory effect of aclidinium, a new… Expand
Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease.
- J. Milara, J. Lluch, P. Almudéver, José Freire, Qian Xiao-zhong, J. Cortijo
- The Journal of allergy and clinical immunology
- 1 August 2014
BACKGROUND Glucocorticoid functions are markedly impaired in patients with chronic obstructive pulmonary disease (COPD). The phosphodiesterase 4 inhibitor roflumilast N-oxide (RNO) is the active… Expand
Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus
- J. Cortijo, J. Bou, +4 authors R. Gristwood
- Chemistry, Medicine
- British journal of pharmacology
- 1 February 1993
1 We have investigated the role of cyclic nucleotide phosphodiesterase IV (PDEIV) in the relaxation of human bronchus and guinea‐pig trachea in vitro and in guinea‐pigs in vivo. 2 Functional studies… Expand
Olive oil-based lipid emulsion's neutral effects on neutrophil functions and leukocyte-endothelial cell interactions.
- Amparo Buenestado, J. Cortijo, +6 authors E. Morcillo
- Medicine, Biology
- JPEN. Journal of parenteral and enteral nutrition
- 1 July 2006
BACKGROUND Infection remains a drawback of parenteral nutrition (PN), probably related, among other factors, to immunosuppressive effects of its lipid component. Newer preparations may have lesser… Expand
N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV).
- M. Mata, E. Morcillo, C. Gimeno, J. Cortijo
- Biology, Medicine
- Biochemical pharmacology
- 1 September 2011
64% of chronic obstructive pulmonary disease (COPD) exacerbations are caused by respiratory infections including influenza (strains A and B) and respiratory syncytial virus (RSV). They affect the… Expand