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perhydrohistrionicotoxin

 
National Institutes of Health

Papers overview

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2010
2010
The total synthesis of the spiropiperidine alkaloid (-)-perhydrohistrionicotoxin (perhydro-HTX) 2 has been accomplished on a gram… Expand
2008
2008
An efficient stereocontrolled route to the spirocyclic perhydrohistrionicotoxin derivative (+/-)-2,7,8-epi-PHTx (4) is described… Expand
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1980
1980
The effects of receptor activation were studied on the interaction of perhydrohistrionicotoxin (H(12)-HTX) with the ionic channel… Expand
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Highly Cited
1979
Highly Cited
1979
After alkaline extraction, purified subsynaptic fragments isolated from Torpedo electric tissue exhibit on sodium dodecyl sulfate… Expand
1979
1979
A tritiated derivative of perhydrohistrionicotoxin was prepared and characterized and used in direct binding studies to membrane… Expand
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1979
1979
Torpedo californica postsynaptic membrane fragments were treated with base, which resulted in membranes that were depleted of… Expand
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Highly Cited
1978
Highly Cited
1978
The electric organ of the ray, Torpedo ocellata, can serve as a source for both the acetylcholine (ACh) receptor and its ionic… Expand
Highly Cited
1977
Highly Cited
1977
Histrionicotoxin from the Colombian frog Dendrobates histrionicus and its perhydro derivative reversibly block the acetylcholine… Expand
1977
1977
Starting from ethyl 2-cyclohexen-1-carboxylate (3) the total synthesis of the perhydrohistrionicotoxin intermediate 23 was… Expand
1977
1977
Summary 3H labeled perhydrohistrionicotoxin binds to acetylcholine receptor enriched membrane fragments with a Kd of 0.43 ± 0.19… Expand