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International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
TLDR
It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics, and it is important to rationalise in concert all of the available data from studies involving both operational approaches of the classical pharmacological type and those from molecular and cellular biology.
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Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors
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Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.
TLDR
It is proposed that preferential stimulation of valvular 5-HT(2B) receptors by norfenfluramine, ergot drugs, or5-HT released from carcinoid tumors (with or without accompanying 5- HT(2A) receptor activation) may contribute to valvial fibroplasia in humans.
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Cloning and expression of a high affinity taurine transporter from rat brain.
TLDR
The structural similarity of the taurine transporter to neurotransmitter transporters is consistent with a neuromodulatory role for taurines in the nervous system and indicates that the transporter mRNA is located in both the brain and peripheral tissues.
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Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain.
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Messenger RNA Editing of the Human Serotonin 5-HT2C Receptor
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Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors*
TLDR
Results indicate that potent and selective γ-secretase inhibitors block Aβ formation by binding to presenilin-1 and -2, and a benzophenone analog specifically photocross-links three major membrane polypeptides.
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Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
TLDR
Competition studies revealed the following rank order of potencies for serotonergic ligands: 5-HT > sumatriptan >> 5-carboxyamidotryptamine > 8-hydroxy-2(di-1-propylamino)tetralin > spiperone.
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Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.
TLDR
Both receptors exhibit high-affinity binding of sumatriptan, a new anti-migraine medication, and thus are candidates for the pharmacological site of action of this drug.
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The 5‐HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.
TLDR
The cloning of the pharmacologically defined 5‐HT4 receptor is reported, and two splice variants of the receptor are isolated, differing in the length and sequence of their C‐termini.
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