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perfosfamide

Known as: cis-2-[bis(2-chloroethyl)amino]tetrahydro-3H-1,3,2-oxazaphosphorin-4-yl hydroperoxide P-oxide, 4'-hydroperoxycyclophosphamide, Hydroperoxycyclophosphamide 
The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties. Perfosfamide alkylates… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

4-Pergamid

Broader (1)

Cyclophosphamide
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

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Highly Cited
2000
Highly Cited
2000
Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells.
Highly Cited
1995
Highly Cited
1995
Effectiveness of controlled release of a cyclophosphamide derivative with polymers against rat gliomas.
Most malignant gliomas grow despite treatment by standard chemotherapeutic agents. The authors explored the use of an innovative… 
Highly Cited
1994
Highly Cited
1994
Rapid acquisition of multicellular drug resistance after a single exposure of mammary tumor cells to antitumor alkylating agents.
BACKGROUND Clinical drug resistance is either intrinsic (de novo) or often acquired rapidly in conjunction with chemotherapy. By… 
1993
1993
Administration of human recombinant granulocyte colony-stimulating factor (filgrastim) accelerates granulocyte recovery following high-dose chemotherapy and autologous marrow transplantation with 4…
Stem cell contamination by tumor is common in many diseases for which autologous bone marrow transplantation is used. In in vitro… 
Highly Cited
1992
Highly Cited
1992
Induction of cutaneous graft-versus-host disease by administration of cyclosporine to patients undergoing autologous bone marrow transplantation for acute myeloid leukemia.
Cutaneous graft-versus-host disease (GVHD) has been reported after administration of cyclosporine (CSP) after autologous bone… 
Highly Cited
1991
Highly Cited
1991
Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes.
NIH3T3 cells transfected with c-H-ras and/or c-myc genes were examined for differences in drug sensitivity. The five… 
Highly Cited
1985
Highly Cited
1985
4-Hydroperoxycyclophosphamide inhibits proliferation by human granulocyte-macrophage colony-forming cells (GM-CFC) but spares more primitive progenitor cells.
Highly Cited
1984
Highly Cited
1984
Preliminary results of high-dose busulfan and cyclophosphamide with syngeneic or autologous bone marrow rescue.
The toxic effects of high-dose busulfan (16 mg/kg) and cyclophosphamide (200 mg/kg) with autologous or syngeneic bone marrow… 
Highly Cited
1982
Highly Cited
1982
Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysis.
The rates at which 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide are converted to phosphoramide mustard and… 
Highly Cited
1981
Highly Cited
1981
In vitro short‐term test to determine the resistance of human tumors to chemotherapy
In a cooperative study conducted by nine different hospitals between 1975 and 1979, the results of a short‐term test in vitro… 
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