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perfosfamide

Known as: cis-2-[bis(2-chloroethyl)amino]tetrahydro-3H-1,3,2-oxazaphosphorin-4-yl hydroperoxide P-oxide, 4'-hydroperoxycyclophosphamide, Hydroperoxycyclophosphamide 
The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties. Perfosfamide alkylates… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

4-Pergamid

Broader (1)

Cyclophosphamide
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

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1992
1992
Escalating the intensity of post-remission therapy improves the outcome in acute myeloid leukemia: the ECOG experience. The Eastern Cooperative Oncology Group.
These ECOG trials have demonstrated that progressive increments in the intensity of post-remission therapy result in improving… 
1987
1987
Marrow purging in autologous bone marrow transplantation for T-lineage acute lymphoblastic leukemia: efficacy of ex vivo treatment with immunotoxins and 4-hydroperoxycyclophosphamide against fresh…
A lymphoblast progenitor cell assay was used to evaluate the antileukemic efficacy of marrow-purging protocols that employed… 
1984
1984
In situ preparation and fate of cis-4-hydroxycyclophosphamide and aldophosphamide: 1H and 31P NMR evidence for equilibration of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and its…
cis-4-Hydroxycyclophosphamide (2) and aldophosphamide (4) were generated in aqueous phosphate or cacodylate buffer by dimethyl… 
1984
1984
Effect of two cyclophosphamide derivatives on hemopoietic progenitor cells and pluripotential stem cells.
The studies described herein were undertaken to help define the effects of certain cyclophosphamide derivatives that have been… 
Review
1983
Review
1983
Teratology testing: I. Development and status of short-term prescreens. II. Biotransformation of teratogens as studied in whole embryo culture.
The development and role of short-term prescreening tests have been described and discussed in the first section. In the second… 
1983
1983
Autologous bone marrow transplantation in acute leukemia and non-Hodgkin's lymphoma: a phase I study of 4-hydroperoxycyclophosphamide (4HC) incubation of marrow prior to cryopreservation.
The presence of occult tumor cells in remission marrow is the initial obstacle to the use of autologous bone marrow… 
1982
1982
Influence of diuretics on urinary general base catalytic activity and cyclophosphamide-induced bladder toxicity.
The influence of diuretics on the induction of bladder toxicity by cyclophosphamide was investigated in rats. Following ip… 
1982
1982
Effect of radiation and 4-hydroperoxycyclophosphamide on thymic regulators of erythropoietic growth.
In vitro growth of erythroid progenitors (BFU-e and CFU-e) from mouse bone marrow (BM) can be influenced by the addition of… 
1976
1976
Permeation of cyclophosphamide (NSC-26271) metabolites into tumor cells.
The permeation kinetics of cyclophosphamide and its metabolites were studied with Ehrlich ascites tumor cells, murine L1210… 
1975
1975
[In-vitro testing of the sensitivity of mammary carcinoma cells to cytostatic drugs (author's transl)].
In-vitro sensitivity to cystostatic agents was tested in 137 cases of breast carcinoma, with 125 tests being analysable…