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perfosfamide

Known as: cis-2-[bis(2-chloroethyl)amino]tetrahydro-3H-1,3,2-oxazaphosphorin-4-yl hydroperoxide P-oxide, 4'-hydroperoxycyclophosphamide, Hydroperoxycyclophosphamide 
The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties. Perfosfamide alkylates… 
National Institutes of Health

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Related topics

4 relations

Narrower (1)

4-Pergamid

Broader (1)

Cyclophosphamide
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

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1994
1994
Combination therapy with nucleoside analogs and alkylating agents.
The nucleoside analog, 2'-deoxycoformycin (dCF), and the alkylating agents, chlorambucil (CLB) and cyclophosphamide, are… 
1992
1992
Escalating the intensity of post-remission therapy improves the outcome in acute myeloid leukemia: the ECOG experience. The Eastern Cooperative Oncology Group.
These ECOG trials have demonstrated that progressive increments in the intensity of post-remission therapy result in improving… 
1987
1987
Marrow purging in autologous bone marrow transplantation for T-lineage acute lymphoblastic leukemia: efficacy of ex vivo treatment with immunotoxins and 4-hydroperoxycyclophosphamide against fresh…
A lymphoblast progenitor cell assay was used to evaluate the antileukemic efficacy of marrow-purging protocols that employed… 
Highly Cited
1984
Highly Cited
1984
Preliminary results of high-dose busulfan and cyclophosphamide with syngeneic or autologous bone marrow rescue.
The toxic effects of high-dose busulfan (16 mg/kg) and cyclophosphamide (200 mg/kg) with autologous or syngeneic bone marrow… 
1984
1984
Effect of two cyclophosphamide derivatives on hemopoietic progenitor cells and pluripotential stem cells.
The studies described herein were undertaken to help define the effects of certain cyclophosphamide derivatives that have been… 
1984
1984
In situ preparation and fate of cis-4-hydroxycyclophosphamide and aldophosphamide: 1H and 31P NMR evidence for equilibration of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and its…
cis-4-Hydroxycyclophosphamide (2) and aldophosphamide (4) were generated in aqueous phosphate or cacodylate buffer by dimethyl… 
Review
1983
Review
1983
Teratology testing: I. Development and status of short-term prescreens. II. Biotransformation of teratogens as studied in whole embryo culture.
The development and role of short-term prescreening tests have been described and discussed in the first section. In the second… 
1982
1982
Influence of diuretics on urinary general base catalytic activity and cyclophosphamide-induced bladder toxicity.
The influence of diuretics on the induction of bladder toxicity by cyclophosphamide was investigated in rats. Following ip… 
1979
1979
[Permeability of N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into tumor cells (author's transl)].
The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by… 
1976
1976
Permeation of cyclophosphamide (NSC-26271) metabolites into tumor cells.
The permeation kinetics of cyclophosphamide and its metabolites were studied with Ehrlich ascites tumor cells, murine L1210…