perfosfamide

Known as: cis-2-[bis(2-chloroethyl)amino]tetrahydro-3H-1,3,2-oxazaphosphorin-4-yl hydroperoxide P-oxide, 4'-hydroperoxycyclophosphamide, Hydroperoxycyclophosphamide 
The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties. Perfosfamide alkylates… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
There has been a new interest in using aldehyde dehydrogenase (ALDH) activity as one marker for stem cells since the Aldefluor… (More)
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Highly Cited
2002
Highly Cited
2002
Recent preclinical studies have shown that frequent administration in vivo of low doses of chemotherapeutic drugs ("metronomic… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE Chronic lymphocytic leukemia (CLL) lymphocytes respond to DNA alkylation by excision repair, with the extent of repair… (More)
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Highly Cited
1998
Highly Cited
1998
Polymeric interstitial chemotherapy increases survival of humans with recurrent gliomas and animals with transplanted tumors in… (More)
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Highly Cited
1998
Highly Cited
1998
Multiple sclerosis is postulated to be a Th1-type cell-mediated autoimmune disease. We investigated cytokine profiles in patients… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Topotecan (TPT) is a topoisomerase I poison that exhibits antineoplastic activity. Analysis of the cytotoxic effects… (More)
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Highly Cited
1991
Highly Cited
1991
The effect of O6-benzylguanine, O6-(p-chlorobenzyl)guanine, and O6-(p-methylbenzyl)guanine on the sensitivity of various human… (More)
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Highly Cited
1991
Highly Cited
1991
We have established cis-diamminedichloroplatinum(II) (cisplatin) resistant human small cell lung cancer cell lines, H69/CDDP0.2… (More)
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Highly Cited
1990
Highly Cited
1990
We prospectively evaluated infusion-related toxicities in 82 recipients of autologous bone marrow grafts. The grafts were… (More)
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Highly Cited
1985
Highly Cited
1985
Development of in vitro resistance to HN2 (also called mustargen or mechlorethamine hydrochloride), N,N'-bis(2-chloroethyl)-N… (More)
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