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Oxidative mechanisms in the toxicity of metal ions.
TLDR
Some mechanisms associated with the toxicities of metal ions are very similar to the effects produced by many organic xenobiotics, related to differences in solubilities, absorbability, transport, chemical reactions, and the complexes that are formed within the body. Expand
In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides.
TLDR
The in vivo effects of structurally dissimilar polyhalogenated cyclic hydrocarbons, such as endrin and chlordane, chlorinated acetamide herbicides, and organophosphate pesticides (OPS), such as chlorpyrifos and fenthion on the production of hepatic and brain lipid peroxidation and DNA-single strand breaks (SSB), two indices of oxidative stress and oxidative tissue damage are examined. Expand
Oxidative mechanisms in the toxicity of chromium and cadmium ions.
TLDR
The results clearly indicate that although different mechanisms lead to the production of reactive oxygen species by chromium and cadmium, similar subsequent mechanisms and types of oxidative tissue damage are involved in the overall toxicities. Expand
Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention.
TLDR
It is demonstrated that GSPE is highly bioavailable and provides significantly greater protection against free radicals and free radical-induced lipid peroxidation and DNA damage than vitamins C, E and beta-carotene. Expand
Oxidative mechanisms in the toxicity of chromium and cadmium ions.
TLDR
The results clearly indicate that although different mechanisms lead to the production of reactive oxygen species by chromium and cadmium, similar subsequent mechanisms and types of oxidative tissue damage are involved in the overall toxicities. Expand
Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase.
TLDR
It is found that the mechanism(s) responsible for the cardioprotective effect of resveratrol in the diabetic myocardium include upregulation of Trx-1, NO/HO- 1, and VEGF in addition to increased MnSOD activity and reduced blood glucose level. Expand
Cytotoxicity and oxidative mechanisms of different forms of chromium.
TLDR
Comparative studies demonstrate that a cascade of cellular events including oxidative stress, genomic DNA damage and modulation of apoptotic regulatory gene p53 are involved in chromium(VI)-induced toxicity and carcinogenesis. Expand
Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract.
TLDR
It is demonstrated that IH636 grape seed proanthocyanidin extract (GSPE) provides superior antioxidant efficacy as compared to Vitamins C, E and beta-carotene and may serve as a potential therapeutic tool in promoting cardiovascular health via a number of novel mechanisms. Expand
Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in
TLDR
GSPE and other antioxidants provided significant protection against TPA-induced oxidative damage, with GSPE providing better protection than did other antioxidants at the doses that were employed. Expand
Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro.
TLDR
GSPE is a more potent scavenger of oxygen free radicals as compared to vitamin C and VES, as well as superoxide dismutase, catalase and mannitol against biochemically generated superoxide anion and hydroxyl radical. Expand
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