peptidyl-tyrosine autophosphorylation

Known as: tyrosine autophosphorylation 
The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. [PMID… (More)
National Institutes of Health

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negative regulation of peptidyl-tyrosine autophosphorylation

Papers overview

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Highly Cited
2008
Highly Cited
2008
Amyloid beta oligomers induce impairment of neuronal insulin receptors.
Recent studies have indicated an association between Alzheimer's disease (AD) and central nervous system (CNS) insulin resistance… (More)
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Highly Cited
2005
Highly Cited
2005
Activation-Loop Autophosphorylation Is Mediated by a Novel Transitional Intermediate Form of DYRKs
Autophosphorylation of a critical residue in the activation loop of several protein kinases is an essential maturation event… (More)
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Highly Cited
2000
Highly Cited
2000
The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor.
Many G protein-coupled receptors (GPCRs) activate MAP kinases by stimulating tyrosine kinase signaling cascades. In some systems… (More)
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Highly Cited
1999
Highly Cited
1999
The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling.
Vascular endothelial growth factor (VEGF) receptor Flk-1/KDR in endothelial cells is activated during vasculogenesis and… (More)
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Highly Cited
1997
Highly Cited
1997
The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated…
Deregulation of signaling by the epidermal growth factor receptor (EGFR) is common in human malignancy progression. One mutant… (More)
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Highly Cited
1995
Highly Cited
1995
Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.
The spitz gene encoding a TGF-alpha homolog, has been shown to affect a subset of developmental processes that are similar to… (More)
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Highly Cited
1994
Highly Cited
1994
Differential complementation of Bcr-Abl point mutants with c-Myc.
A complementation strategy was developed to define the signaling pathways activated by the Bcr-Abl tyrosine kinase… (More)
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Highly Cited
1994
Highly Cited
1994
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
Activation of growth factor receptors results in tyrosine autophosphorylation and recruitment of SH2 domain-containing effectors… (More)
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Highly Cited
1993
Highly Cited
1993
Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.
Stimulation of aortic smooth muscle cells with platelet-derived growth factor BB homodimer (PDGF-BB) leads to the rapid… (More)
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Highly Cited
1985
Highly Cited
1985
The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling
A cloned approximately 5 kb cDNA (human placenta) contains the coding sequences for the insulin receptor. The nucleotide sequence… (More)
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