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penicillin biosynthetic process

Known as: penicillin synthesis, penicillin anabolism, penicillin biosynthesis 
The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1947-2016
051019472015

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2 relations
negative regulation of penicillin biosynthetic processregulation of penicillin biosynthetic process

Related mentions per year

Related mentions per year

1948-2017
19401960198020002020
penicillin biosynthetic process
negative regulation of penicillin biosynthetic process
regulation of penicillin biosynthetic process

Papers overview

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Highly Cited
2010
Highly Cited
2010
Two components of a velvet-like complex control hyphal morphogenesis, conidiophore development, and penicillin biosynthesis in Penicillium chrysogenum.
Penicillium chrysogenum is the industrial producer of the antibiotic penicillin, whose biosynthetic regulation is barely… (More)
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2009
2009
The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum.
The biosynthesis of the beta-lactam antibiotic penicillin is an excellent model for the study of secondary metabolites produced… (More)
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Highly Cited
2008
Highly Cited
2008
Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum
Industrial penicillin production with the filamentous fungus Penicillium chrysogenum is based on an unprecedented effort in… (More)
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Highly Cited
2003
Highly Cited
2003
The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development.
Secondary metabolism is commonly associated with morphological development in microorganisms, including fungi. We found that veA… (More)
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1997
1997
Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
The biosynthesis of penicillin and cephalosporin antibiotics in microorganisms requires the formation of the bicyclic nucleus of… (More)
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1997
1997
Analysis of a commercially improved Penicillium chrysogenum strain series: involvement of recombinogenic regions in amplification and deletion of the penicillin biosynthesis gene cluster
Several commercially improved strains of Penicillium chrysogenum have been shown to carry amplifications of the entire penicillin… (More)
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1996
1996
Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence
The organization of the genes of the penicillin cluster has been studied in three different mutants of P. chrysogenum impaired in… (More)
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Highly Cited
1995
Highly Cited
1995
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
Penicillin antibiotics are all produced from fermentation-derived penicillins because their chemical synthesis is not… (More)
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Highly Cited
1992
Highly Cited
1992
Involvement of microbodies in penicillin biosynthesis.
Penicillium chrysogenum strains were constructed which express a mutant acyltransferase lacking the putative targeting signal for… (More)
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1990
1990
The multifunctional peptide synthetase performing the first step of penicillin biosynthesis in Penicillium chrysogenum is a 421,073 dalton protein similar to Bacillus brevis peptide antibiotic…
The nucleotide sequence of the Penicillium chrysogenum Oli13 acvA gene encoding delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine… (More)
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