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penicillin biosynthetic process
Known as:
penicillin synthesis
, penicillin anabolism
, penicillin biosynthesis
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The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system…
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National Institutes of Health
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Related topics
Related topics
2 relations
negative regulation of penicillin biosynthetic process
positive regulation of penicillin biosynthetic process
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Genes for β-lactam antibiotic biosynthesis
J. Martín
,
S. Gutiérrez
Antonie van Leeuwenhoek
2004
Corpus ID: 35166839
The genespcbAB,pcbC andpenDE encoding enzymes involved in the biosynthesis of penicillin have been cloned fromPenicillium…
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Highly Cited
1989
Highly Cited
1989
delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Aspergillus nidulans. The first enzyme in penicillin biosynthesis is a multifunctional peptide synthetase.
H. Liempt
,
H. Döhren
,
Horst Kleinkauf
Journal of Biological Chemistry
1989
Corpus ID: 12485022
A multienzyme catalyzing the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine, the first free intermediate in…
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Highly Cited
1986
Highly Cited
1986
alpha-Aminoadipate pool concentration and penicillin biosynthesis in strains of Penicillium chrysogenum.
W. Jaklitsch
,
W. Hampel
,
M. Röhr
,
C. Kubicek
,
G. Gamerith
Canadian Journal of Microbiology (print)
1986
Corpus ID: 41439760
Intracellular amino acid pools in four Penicillium chrysogenum strains, which differed in their ability to produce penicillin…
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1985
1985
Characterization of the biosynthesis in vivo of α-aminoadipyl-cysteinyl-valine inPenicillium chrysogenum
M. López-Nieto
,
F. Ramos
,
J. Luengo
,
J. Martín
Applied Microbiology and Biotechnology
1985
Corpus ID: 37887155
SummaryThe parameters affecting the formation in vivo of α-aminoadipyl-cysteinyl-valine (ACV), an intermediate in penicillin…
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Highly Cited
1984
Highly Cited
1984
A pure enzyme catalyzing penicillin biosynthesis.
I. Hollander
,
Y. Q. Shen
,
J. Heim
,
A. Demain
,
S. Wolfe
Science
1984
Corpus ID: 21240233
Isopenicillin N synthetase (cyclase) has been purified to homogeneity from Cephalosporium acremonium strain C-10. The enzyme has…
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Highly Cited
1979
Highly Cited
1979
Lysine regulation of penicillin biosynthesis in low-producing and industrial strains of Penicillium chrysogenum.
J. Luengo
,
G. Revilla
,
J. R. Villanueva
,
J. Martín
Journal of General Microbiology
1979
Corpus ID: 42031234
The inhibitory effect of L-lysine on penicillin biosynthesis by Penicillium chrysogenum has been compared in a low-producing…
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1977
1977
Homocitrate synthase as the crucial site of the lysine effect on penicillin biosynthesis.
Cornelius G. Friedrich
,
A. L. Demain
Journal of antibiotics (Tokyo. )
1977
Corpus ID: 35805576
Homocitrate reverses the lysine inhibition of penicillin bisynthesis. Since lysine is known to inhibit homocitrate synthase…
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Highly Cited
1976
Highly Cited
1976
Synthesis of delta-(alpha-aminoadipyl)cysteinylvaline and its role in penicillin biosynthesis.
P. Fawcett
,
J. J. Usher
,
J. Huddleston
,
R. C. Bleaney
,
J. Nisbet
,
E. Abraham
Biochemical Journal
1976
Corpus ID: 7487199
1. The stereoisomers of delta-(alpha-aminoadipyl)-L-cysteinylvaline (LLD, LLL and DLD) were synthesized from valine labelled with…
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1960
1960
Influence of valine, isoleucine, and related compounds on actinomycin synthesis.
E. Katz
Journal of Biological Chemistry
1960
Corpus ID: 39991381
Highly Cited
1948
Highly Cited
1948
Biosynthesis of penicillins; new crystalline biosynthetic penicillins.
Behrens Ok
,
J. Corse
Journal of Biological Chemistry
1948
Corpus ID: 5540603
Paper III (1) in this series describes several tests which were found to be useful in determining whether a given compound is…
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