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An Enzyme from Bacteria able to Destroy Penicillin
It is confirmed that the growth of B. coli and a number of other bacteria belonging to the colityphoid group was not inhibited by penicillin, and the cause of the resistance of these organisms to the action of Penicillin is found. Expand
FURTHER OBSERVATIONS ON PENICILLIN
The structure of bacilysin and other products of Bacillus subtilis.
The results revealed the absolute stereochemistry and enabled a definitive structure to be assigned to the molecule and these results are discussed in relation to the biogenesis of bacilysin. Expand
Antimicrobial activities and antagonists of bacilysin and anticapsin.
The dipeptide antibiotic bacilysin is active against a wide range of bacteria and against Candida albicans and its C-terminal amino acid, anticapsin, is a very poor antibacterial agent and may interfere with glucosamine synthesis and thus with the synthesis of microbial cell walls. Expand
Transport and metabolism of bacilysin and other peptides by suspensions of Staphylococcus aureus.
The behaviour of these dipeptides paralleled the inactivation of bacilysin by suspensions of S. aureus and the appearance of its C-terminal amino acid, anticapsin, in the extracellular fluid. Expand
The biosynthesis of penicillins and cephalosporins.
The mode of action of bacilysin and anticapsin and biochemical properties of bacilysin-resistant mutants.
It is suggested that the antibacterial activity of bacilysin depends on its transport into the organism, its hydrolysis to anticapsin and on inhibition by the latter of glucosamine synthetase, and that b Bacilysin-resistant mutants are defective in a transport system. Expand
Zinc as a cofactor for cephalosporinase from Bacillus cereus 569.
Cephalosporinase and penicillinase activities of a beta-lactamase from Pseudomonas pyocyanea.
The latter might show synergism with the enzyme inhibitors, methicillin and cloxacillin, against this organism, and it was concluded that the production of a beta-lactamase contributed to the factors responsible for the very high resistance of Ps. Expand