pembrolizumab

Known as: Immunoglobulin G4, Anti-(Human Programmed Cell Death 1); Humanized Mouse Monoclonal (228-L-proline(H10-S>P))gamma 4 Heavy Chain (134-218')-disulfide with Humanized Mouse Monoclonal Kappa Light Chain Dimer (226-226'':229-229'')-bisdisulfide, Lambrolizumab 
A humanized monoclonal immunoglobulin (Ig) G4 antibody directed against human cell surface receptor PD-1 (programmed death-1 or programmed cell death… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1953-2018
010020030019532017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
BACKGROUND Patients with advanced urothelial carcinoma that progresses after platinum-based chemotherapy have a poor prognosis… (More)
  • table 1
  • figure 1
  • figure 3
  • table 2
Is this relevant?
Review
2016
Review
2016
Several immunomodulatory checkpoint inhibitors have been approved for the treatment of patients with advanced melanoma, including… (More)
  • figure 1
  • figure 2
  • table 1
  • table 1
Is this relevant?
Highly Cited
2016
Highly Cited
2016
BACKGROUND Despite recent advances in the treatment of advanced non-small-cell lung cancer, there remains a need for effective… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2016
Highly Cited
2016
BACKGROUND Merkel-cell carcinoma is an aggressive skin cancer that is linked to exposure to ultraviolet light and the Merkel-cell… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
2016
Highly Cited
2016
PURPOSE Immune checkpoint inhibition has been demonstrated to be an effective anticancer strategy. Several lines of evidence… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • figure 2
Is this relevant?
Highly Cited
2016
Highly Cited
2016
PURPOSE We evaluated atypical response patterns and the relationship between overall survival and best overall response measured… (More)
  • table 1
  • figure 2
  • figure 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2015
Highly Cited
2015
BACKGROUND The immune checkpoint inhibitor ipilimumab is the standard-of-care treatment for patients with advanced melanoma… (More)
Is this relevant?
Highly Cited
2015
Highly Cited
2015
BACKGROUND Patients with melanoma that progresses on ipilimumab and, if BRAF(V600) mutant-positive, a BRAF or MEK inhibitor or… (More)
Is this relevant?
Highly Cited
2015
Highly Cited
2015
Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are revolutionizing cancer treatment. To… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2014
Highly Cited
2014
Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durable clinical responses in… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?