pegaspargase

Known as: pegylated asparaginase, L-asparagine amidohydrolase, (Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase 
A complex of polyethylene glycol conjugated with L-asparaginase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
PURPOSE Retrospective comparisons have suggested that adolescents or teenagers with acute lymphoblastic leukemia (ALL) benefit… (More)
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Highly Cited
2007
Highly Cited
2007
On July 24, 2006, the U.S. Food and Drug Administration granted approval to pegaspargase (Oncaspar; Enzon Pharmaceuticals, Inc… (More)
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Highly Cited
2004
Highly Cited
2004
Various transplantation strategies have been designed to improve the poor prognosis of adult (ages 15 to 60 years) acute… (More)
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Highly Cited
2002
Highly Cited
2002
Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in children. It has… (More)
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Highly Cited
2000
Highly Cited
2000
We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell lines used in a drug discovery screen by the… (More)
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Highly Cited
2000
Highly Cited
2000
Trial ALL-BFM 90 was designed to improve outcome in patients with childhood acute lymphoblastic leukemia (ALL) by using a reduced… (More)
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2000
2000
BACKGROUND The purpose of this study is to report the incidence of pancreatitis in patients treated with pegaspargase in our… (More)
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Review
1998
Review
1998
Owing to the high efficacy of L-asparaginase in the treatment of acute lymphatic leukaemia the enzyme was introduced into the… (More)
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Highly Cited
1997
Highly Cited
1997
As an important determinant of the response to chemotherapy, measurements of cellular drug resistance may provide prognostically… (More)
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Highly Cited
1973
Highly Cited
1973
L-Asparaginase and L-glutaminase activities were detected in many microorganisms and the distribution of these activities was… (More)
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