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pegaspargase

Known as: pegylated asparaginase, L-asparagine amidohydrolase, (Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase 
A complex of polyethylene glycol conjugated with L-asparaginase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby… 
National Institutes of Health

Related topics

Related topics

14 relations
5 ML pegaspargase 750 UNT/ML Injection [Oncaspar]ASPARAGINASEBlast PhaseChronic Lymphocytic Leukemia

Broader (2)

Antineoplastic AgentsPolyethylene Glycols

Narrower (1)

Oncaspar

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and intermediate-risk acute lymphoblastic leukaemia…
Highly Cited
2004
Highly Cited
2004
Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: a GOELAMS trial.
Various transplantation strategies have been designed to improve the poor prognosis of adult (ages 15 to 60 years) acute… 
Highly Cited
2004
Highly Cited
2004
Asparaginase Antibody and Asparaginase Activity in Children With Higher-Risk Acute Lymphoblastic Leukemia: Children's Cancer Group Study CCG-1961
We investigated the anti-asparaginase antibody (Ab) and asparaginase enzymatic activity in the sera of 1,001 patients (CCG-1961… 
Highly Cited
2000
Highly Cited
2000
Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group.
Trial ALL-BFM 90 was designed to improve outcome in patients with childhood acute lymphoblastic leukemia (ALL) by using a reduced… 
Review
1999
Review
1999
The Thrombophilic State Induced by Therapeutic Agents in the Cancer Patient
L 
Highly Cited
1995
Highly Cited
1995
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
The goal of this phase II multicenter clinical trial was to evaluate a new intensive chemotherapy program for adults with… 
Highly Cited
1995
Highly Cited
1995
In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia.
Cellular drug resistance is thought to be an important cause of the poor prognosis for children with relapsed or refractory acute… 
Highly Cited
1994
Highly Cited
1994
Increased endogenous thrombin generation in children with acute lymphoblastic leukemia: risk of thrombotic complications in L'Asparaginase-induced antithrombin III deficiency.
Pediatric patients with acute lymphoblastic leukemia (ALL) are at an increased risk of thromboembolic events. Potential… 
Highly Cited
1979
Highly Cited
1979
Results of treatment of Ph'+ chronic myelogenous leukemia with an intensive treatment regimen (L-5 protocol).
Thirty-seven patients with Philadelphia-chromosone-positive (Ph'+) chronic myelogenous leukemia who were untreated or minimally… 
Highly Cited
1963
Highly Cited
1963
EVIDENCE THAT THE L-ASPARAGINASE OF GUINEA PIG SERUM IS RESPONSIBLE FOR ITS ANTILYMPHOMA EFFECTS
Cells of the original line of lymphoma 6C3HED, which regularly prove susceptible to the effects of guinea pig serum in vivo, were… 
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