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ASPARAGINASE

Known as: Lcf-ASP, Deaminase, Asparagine, ASP-1 
An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L… Expand
National Institutes of Health

Papers overview

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Review
2012
Review
2012
The utility of anthracycline antineoplastic agents in the clinic is compromised by the risk of cardiotoxicity. It has been… Expand
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Highly Cited
2007
Highly Cited
2007
Rapid clearance of poly(ethylene glycol)‐asparaginase (PEG‐ASNase) has been reported for up to one‐third of patients treated for… Expand
Highly Cited
2002
Highly Cited
2002
Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in children. It has… Expand
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Highly Cited
2000
Highly Cited
2000
We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell lines used in a drug discovery screen by the… Expand
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Review
1998
Review
1998
Owing to the high efficacy of L-asparaginase in the treatment of acute lymphatic leukaemia the enzyme was introduced into the… Expand
Highly Cited
1997
Highly Cited
1997
A pH and dye‐based fast procedure for screening l‐asparaginase‐producing micro‐organisms is reported. The procedure is suitable… Expand
Highly Cited
1993
Highly Cited
1993
PURPOSE As part of pharmacologic studies of asparaginase (ASNase), we determined the half-life of ASNase activity and protein… Expand
Highly Cited
1987
Highly Cited
1987
Peptides containing the tripeptide sequence Arg-Gly-Asp can duplicate or inhibit the cell attachment-promoting effects of… Expand
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Highly Cited
1977
Highly Cited
1977
An undifferentiated human pancreatic carcinoma has been established in continuous culture and is grown in Dulbecco's modified… Expand
Highly Cited
1967
Highly Cited
1967
Enzyme therapy directed at depletion of an amino acid, asparagine, indispensable for tumor cell growth but not required by normal… Expand