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The utility of anthracycline antineoplastic agents in the clinic is compromised by the risk of cardiotoxicity. It has been… Expand Rapid clearance of poly(ethylene glycol)‐asparaginase (PEG‐ASNase) has been reported for up to one‐third of patients treated for… Expand Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in children. It has… Expand We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell lines used in a drug discovery screen by the… Expand Owing to the high efficacy of L-asparaginase in the treatment of acute lymphatic leukaemia the enzyme was introduced into the… Expand A pH and dye‐based fast procedure for screening l‐asparaginase‐producing micro‐organisms is reported. The procedure is suitable… Expand PURPOSE
As part of pharmacologic studies of asparaginase (ASNase), we determined the half-life of ASNase activity and protein… Expand Peptides containing the tripeptide sequence Arg-Gly-Asp can duplicate or inhibit the cell attachment-promoting effects of… Expand An undifferentiated human pancreatic carcinoma has been established in continuous culture and is grown in Dulbecco's modified… Expand Enzyme therapy directed at depletion of an amino acid, asparagine, indispensable for tumor cell growth but not required by normal… Expand