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ASPARAGINASE

Known as: Lcf-ASP, Deaminase, Asparagine, ASP-1 
An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who… Expand
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Highly Cited
2008
Highly Cited
2008
Acrylamide formation in French fries was investigated in relation to blanching and asparaginase soaking treatments before final… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Rapid clearance of poly(ethylene glycol)-asparaginase (PEG-ASNase) has been reported for up to one-third of patients… Expand
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Highly Cited
2004
Highly Cited
2004
L-asparaginase production was investigated in the filamentous fungi Aspergillus tamarii and Aspergillus terreus. The fungi were… Expand
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Highly Cited
2002
Highly Cited
2002
Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in children. It has… Expand
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Highly Cited
2000
Highly Cited
2000
We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell lines used in a drug discovery screen by the… Expand
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Review
1998
Review
1998
Owing to the high efficacy of L-asparaginase in the treatment of acute lymphatic leukaemia the enzyme was introduced into the… Expand
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Highly Cited
1997
Highly Cited
1997
A pH and dye-based fast procedure for screening L-asparaginase producing micro-organisms is reported. The procedure is suitable… Expand
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Highly Cited
1993
Highly Cited
1993
PURPOSE As part of pharmacologic studies of asparaginase (ASNase), we determined the half-life of ASNase activity and protein… Expand
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Highly Cited
1977
Highly Cited
1977
An undifferentiated human pancreatic carcinoma has been established in continuous culture and is grown in Dulbecco's modified… Expand
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