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ASPARAGINASE

Known as: Lcf-ASP, Deaminase, Asparagine, ASP-1 
An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L… 
National Institutes of Health

Related topics

Related topics

39 relations

Narrower (17)

AIEOP protocol 8202Asparaginase medacAsrgl1 protein, ratCrasnitin

Broader (2)

AmidohydrolasesAntineoplastic Agents
AspartateCOPAD protocolErwinia asparaginase 10000 UNT InjectionIn Blood

Papers overview

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Review
1998
Review
1998
Use of L-asparaginase in childhood ALL.
Highly Cited
1998
Highly Cited
1998
Anandamide amidohydrolase reacting with 2‐arachidonoylglycerol, another cannabinoid receptor ligand
Highly Cited
1997
Highly Cited
1997
A rapid plate assay for screening l‐asparaginase producing micro‐organisms
A pH and dye‐based fast procedure for screening l‐asparaginase‐producing micro‐organisms is reported. The procedure is suitable… 
Highly Cited
1993
Highly Cited
1993
Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy.
The crystal structure of Escherichia coli asparaginase II (EC 3.5.1.1), a drug (Elspar) used for the treatment of acute… 
Review
1993
Review
1993
L-asparaginase and PEG asparaginase--past, present, and future.
L-asparaginase is an enzyme which hydrolyses asparagine. Since the 1960s it has been known that some leukemic cells are deficient… 
Highly Cited
1984
Highly Cited
1984
Excitatory amino acids directly depolarize rat brain astrocytes in primary culture
L-glutamic acid (L-Glu) and L-aspartic acid (L-Asp) are considered to be major excitatory amino acid transmitters, causing… 
Highly Cited
1983
Highly Cited
1983
Influence of intensive asparaginase in the treatment of childhood non-T-cell acute lymphoblastic leukemia.
Between June 1977 and December 1979, 72 evaluable patients with childhood non-T-cell acute lymphoblastic leukemia were induced… 
Highly Cited
1976
Highly Cited
1976
Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat.
The effects of both synthetic and biologically produced angiotensin II (AII) upon the process of glolerular filtration were… 
Highly Cited
1967
Highly Cited
1967
L-asparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia.
Enzyme therapy directed at depletion of an amino acid, asparagine, indispensable for tumor cell growth but not required by normal… 
Highly Cited
1963
Highly Cited
1963
EVIDENCE THAT THE L-ASPARAGINASE OF GUINEA PIG SERUM IS RESPONSIBLE FOR ITS ANTILYMPHOMA EFFECTS
Cells of the original line of lymphoma 6C3HED, which regularly prove susceptible to the effects of guinea pig serum in vivo, were… 
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