ASPARAGINASE

Known as: Lcf-ASP, Deaminase, Asparagine, ASP-1 
An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1937-2018
010020019372017

Papers overview

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Highly Cited
2011
Highly Cited
2011
Extranodal NK/T-cell lymphoma, nasal type, is a rare and highly aggressive disease with a grim prognosis. No therapeutic strategy… (More)
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Highly Cited
2007
Highly Cited
2007
Because of their low asparagine synthetase (ASNS) expression and asparagine biosynthesis, acute lymphoblastic leukemia (ALL… (More)
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Highly Cited
2004
Highly Cited
2004
We investigated the anti-asparaginase antibody (Ab) and asparaginase enzymatic activity in the sera of 1,001 patients (CCG-1961… (More)
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Highly Cited
2002
Highly Cited
2002
Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in children. It has… (More)
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Highly Cited
2002
Highly Cited
2002
For this study, 118 children with standard-risk acute lymphoblastic leukemia (ALL) were given randomized assignments to receive… (More)
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Highly Cited
2000
Highly Cited
2000
We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell lines used in a drug discovery screen by the… (More)
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Highly Cited
1999
Highly Cited
1999
This study was designed to test the hypothesis that high-dose asparaginase consolidation therapy improves survival in pediatric… (More)
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Highly Cited
1996
Highly Cited
1996
The antileukaemic enzyme L-asparaginase is used to achieve the greatest possible reduction in blood levels of the amino acid… (More)
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Highly Cited
1993
Highly Cited
1993
PURPOSE As part of pharmacologic studies of asparaginase (ASNase), we determined the half-life of ASNase activity and protein… (More)
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Highly Cited
1963
Highly Cited
1963
A number of the properties of the L-asparaginase present in guinea pig serum have been examined and shown to be indistinguishable… (More)
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