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parathyroid hormone-related protein

Known as: PTH Related Peptide, Parathyrin related protein, PTHrP 
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It… 
National Institutes of Health

Related topics

Related topics

27 relations
HypercalcemiaIn BloodPTHLH genePTHLH wt Allele

Narrower (9)

PTHLH protein, humanabaloparatideparathyroid hormone-related peptide (1-36)parathyroid hormone-related peptide (38-64)

Broader (1)

peptide hormone

Papers overview

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Review
2013
Review
2013
Parathyroid Hormone and Parathyroid Hormone-Related Protein Analogs as Therapies for Osteoporosis
Osteoporotic fractures result in significant morbidity and mortality. Anabolic agents reverse the negative skeletal balance that… 
Highly Cited
2004
Highly Cited
2004
Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice.
We investigated the relative contributions of PTH and PTHrP to the skeletal phenotype of mice deficient in PTH (PTH(-/-)). PTH… 
Highly Cited
2003
Highly Cited
2003
Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation.
Large amounts of calcium are transferred to offspring by milk. This demand results in negative calcium balance in lactating… 
Highly Cited
2001
Highly Cited
2001
The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones.
In the growth plate of endochondral bones, parathyroid hormone (PTH)-related peptide (PTHrP) regulates the rate of chondrocyte… 
Highly Cited
1998
Highly Cited
1998
A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia.
We describe a patient with Blomstrand chondrodysplasia, a lethal genetic disorder characterized by extremely advanced… 
Review
1997
Review
1997
Parathyroid hormone‐related protein and hypercalcemia
The discovery of parathyroid hormone‐related protein (PTH‐rP) arose from interest in the mechanisms by which certain cancers… 
Review
1994
Review
1994
Parathyroid hormone-related protein as a prohormone: posttranslational processing and receptor interactions.
Since the elucidation of the structures of the three human PRHrP isoforms in 1987, information has rapidly accured which… 
Highly Cited
1993
Highly Cited
1993
Parathyroid hormone-parathyroid hormone related protein receptor messenger RNA is present in many tissues besides the kidney.
Parathyroid hormone (PTH) acts on a large number of cells derived from many different tissues that are not traditional targets… 
Highly Cited
1984
Highly Cited
1984
Age-related changes in parathyroid hormone and parathyroid hormone action in normal humans.
We evaluated parathyroid function in 158 normal subjects, aged 23-85 yr. Calcium, phosphorus, creatinine, and cAMP were measured… 
Highly Cited
1977
Highly Cited
1977
On the pathogenesis of so-called idiopathic hypercalciuria.
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