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High Bone Resorption in Adult Aging Transgenic Mice Overexpressing Cbfa1/Runx2 in Cells of the Osteoblastic Lineage
ABSTRACT The runt family transcription factor core-binding factor α1 (Cbfa1) is essential for bone formation during development. Surprisingly, transgenic mice overexpressing Cbfa1 under the controlExpand
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Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.
Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a vital role in the resorption and remodeling of bone. PycnodysostosisExpand
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Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures.
We developed a mouse bone marrow culture system to examine the process of osteoclast-like multinucleated cell formation from its progenitors. When mouse marrow cells were cultured for 8 days with 1Expand
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The structure and development of mammalian enamel.
A web of polymeric foam which is sealed on one or both sides by a thin, hard plastic layer is disclosed. The sealed web is prepared by coating an auxiliary substrate with a film of hardExpand
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Nanomechanical properties and mineral concentration in articular calcified cartilage and subchondral bone.
We studied articular calcified cartilage (ACC) and the immediately subchondral bone (SCB) in normal and osteoarthritic human femoral heads. Thick slices of human normal reference post mortem (PM) andExpand
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Phenotypic Effects of Biglycan Deficiency Are Linked to Collagen Fibril Abnormalities, Are Synergized by Decorin Deficiency, and Mimic Ehlers‐Danlos‐Like Changes in Bone and Other Connective Tissues
  • A. Corsi, T. Xu, +9 authors M. Young
  • Medicine, Biology
  • Journal of bone and mineral research : the…
  • 1 July 2002
Decorin (dcn) and biglycan (bgn), two members of the family of small leucine‐rich proteoglycans (SLRPs), are the predominant proteoglycans expressed in skin and bone, respectively. TargetedExpand
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Functional associations between collagen fibre orientation and locomotor strain direction in cortical bone of the equine radius
A novel technique for determining the collagen fibre orientation pattern of cross-sections of cortical bone was used to study mid-diaphyseal sections from the equine radius. Several in vivo strainExpand
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The Principles and Practice of Electron Microscopy.
Any books that you read, no matter how you got the sentences that have been read from the books, surely they will give you goodness. But, we will show you one of recommendation of the book that youExpand
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Lamellar Bone is an Incremental Tissue Reconciling Enamel Rhythms, Body Size, and Organismal Life History
Mammalian enamel formation is periodic, including fluctuations attributable to the daily biological clock as well as longer-period oscillations that enigmatically correlate with body mass. BecauseExpand
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The relationship between the chemistry and biological activity of the bisphosphonates.
The ability of bisphosphonates ((HO)(2)P(O)CR(1)R(2)P(O)(OH)(2)) to inhibit bone resorption has been known since the 1960s, but it is only recently that a detailed molecular understanding of theExpand
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