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From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health.
  • A. Norman
  • Biology, Medicine
  • The American journal of clinical nutrition
  • 1 August 2008
New knowledge of the biological and clinical importance of the steroid hormone 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] and its receptor, the vitamin D receptor (VDR), has resulted inExpand
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Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)₂vitamin D₃: genomic and non-genomic mechanisms.
The conformationally flexible secosteroid, 1α,25(OH)₂vitamin D₃ (1α,25(OH)₂D₃) initiates biological responses via binding to the vitamin D receptor (VDR). The VDR contains two overlapping ligandExpand
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Structure-function relationships in the vitamin D endocrine system.
I. Vitamin D Endocrine System RESEARCH directed at defining the molecular mode of action of vitamin D is currently at its apex. There is now evidence implicating the essential involvement of vitaminExpand
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The urgent need to recommend an intake of vitamin D that is effective.
This editorial makes the point that there is now strong evidence that increasing vitamin D intake will lower risk of falling and lower fracture risk in older men and women. There is also strongExpand
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Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
Steroid hormones can act as chemical messengers in a wide range of species and target tissues to produce both slow genomic responses, and rapid non-genomic responses. Although it is clear thatExpand
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Minireview: vitamin D receptor: new assignments for an already busy receptor.
  • A. Norman
  • Biology, Medicine
  • Endocrinology
  • 1 December 2006
With its discovery in 1920, the molecule vitamin D achieved prominence as a nutritionally essential vitamin important for calcium homeostasis, particularly in the intestine and bone. Then in 1932,Expand
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Monoclonal antibodies directed against the calcium binding protein Calbindin D-28k.
We have produced 25 clones secreting antibodies directed against chicken Calbindin D-28k. Two of them, 300 and 318, recognize determinants conserved in fish, chicken, mouse, rat, rabbit, monkey andExpand
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The role of the vitamin D endocrine system in health and disease.
The secosteroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the major biologically active metabolite of vitamin D3. (Secosteroids are those in which one of the rings has undergone fission; in...
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1α,25‐Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action
We reported recently that suppression of the renal lα,25‐dihyroxyvitamin D3 (lα,25‐(OH)2‐D3) production in aP2‐agouti transgenic mice by increasing dietary calcium decreases adipocyte intracellularExpand
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Vitamin D nutritional policy needs a vision for the future
Historically vitamin D is known to be essential for normal bone growth and quality, and thus appropriate dietary vitamin D supplementation can eliminate vitamin D deficiency childhood rickets andExpand
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