p21 K-Ras Protein

Known as: p21 c K ras, p21, c-Ki-ras, c-K-ras, p21 
p21 K-RAS protein is encoded by the K-RAS gene. Two KRAS isoforms are produced by alternative splicing. RAS proteins are involved in transmembrane… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but… (More)
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Highly Cited
2013
Highly Cited
2013
The KRAS oncogene product is considered a major target in anticancer drug discovery. However, direct interference with KRAS… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Mutations in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) play a critical role in cancer cell… (More)
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Highly Cited
2011
Highly Cited
2011
The STAT3 transcription factor is an important regulator of stem cell self-renewal, cancer cell survival, and inflammation. In… (More)
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Highly Cited
2010
Highly Cited
2010
Otto Warburg's theory on the origins of cancer postulates that tumor cells have defects in mitochondrial oxidative… (More)
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Highly Cited
2010
Highly Cited
2010
Aberrantly expressed microRNA (miRNA) is frequently associated with a variety of cancers, including pancreatic ductal… (More)
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Highly Cited
2009
Highly Cited
2009
Tumor progression is driven by genetic mutations, but little is known about the environmental conditions that select for these… (More)
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Highly Cited
2009
Highly Cited
2009
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard… (More)
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Highly Cited
2006
Highly Cited
2006
In human and mouse, the promoter of the KRAS gene contains a nuclease hypersensitive polypurine-polypyrimidine element (NHPPE… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND & AIMS Synchronous activation of the Wnt signaling pathway, mostly because of loss of function of the APC tumor… (More)
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