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p21 K-Ras Protein

Known as: p21 c K ras, p21, c-Ki-ras, c-K-ras, p21 
p21 K-RAS protein is encoded by the K-RAS gene. Two KRAS isoforms are produced by alternative splicing. RAS proteins are involved in transmembrane… 
National Institutes of Health

Related topics

Related topics

11 relations
Berzofsky Ras/P53 Peptide VaccineGTP BindingGTP Binding DomainGuanosine Triphosphate Phosphohydrolases

Broader (1)

Proto-Oncogene Proteins p21(ras)

Papers overview

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Highly Cited
2012
Highly Cited
2012
KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells.
BACKGROUND We previously found that oncogenic KRAS induces increased expression of microRNAs (miRNAs), such as miR-200c and miR… 
2006
2006
Mutation analysis of ras gene in the liver of European eel (Anguilla anguilla L.) exposed to benzo[a]pyrene.
Highly Cited
2002
Highly Cited
2002
Advantages, Opportunities and Limits of Empirical Evaluations: Evaluating Adaptive Systems
While empirical evaluations are a common research method in some areas of Artificial Intelligence (AI), others still neglect this… 
Highly Cited
2001
Highly Cited
2001
Dual role of H-Ras in regulation of lymphocyte function antigen-1 activity by stromal cell-derived factor-1alpha: implications for leukocyte transmigration.
We investigated the role of H-Ras in chemokine-induced integrin regulation in leukocytes. Stimulation of Jurkat T cells with the… 
Highly Cited
1997
Highly Cited
1997
Oncogenic Ki-ras but Not Oncogenic Ha-rasBlocks Integrin β1-Chain Maturation in Colon Epithelial Cells*
Human colorectal tumors commonly contain mutations in Ki-ras but rarely, if ever, in Ha-ras. The selectivity for Ki-ras mutations… 
Highly Cited
1996
Highly Cited
1996
The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium
We have recently shown that the neuronal exchange factor p140 Ras-GRF becomes activated in vivo in response to elevated calcium… 
Highly Cited
1996
Highly Cited
1996
Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits.
Muscarinic receptors activate Ras through a pathway distinct from that mediated through translocation of the exchange factor… 
Highly Cited
1995
Highly Cited
1995
Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals.
Ras-GRF, a guanine-nucleotide exchange factor that activates Ras p21, was tested for its ability to couple to either tyrosine… 
Highly Cited
1994
Highly Cited
1994
The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner.
R-ras is a member of the ras family of small GTPases that associates with the apoptosis-suppressing proto-oncogene product Bcl-2… 
Highly Cited
1993
Highly Cited
1993
p21ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells.
In T cells, signals initiated at the TCR, and in particular activation of protein kinase C (PKC), can activate the p21ras… 
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