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Cell cycle, CDKs and cancer: a changing paradigm
Genetic evidence suggests that tumour cells may also require specific interphase CDKs for proliferation, and selective CDK inhibition may provide therapeutic benefit against certain human neoplasias.
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
The Trk family of neurotrophin receptors.
- M. Barbacid
- BiologyJournal of neurobiology
- 1 November 1994
Preliminary characterization of these mutant mice has provided significant information regarding the role of these receptors in the ontogeny of the mammalian nervous system, and TrkC-deficient mice display strikingly abnormal movements consistent with loss of proprioception.
Renal agenesis and the absence of enteric neurons in mice lacking GDNF
Mice defective in GDNF expression are generated by using homologous recombination in embryonic stem cells to delete each of its two coding exons, and ablation of the GDNF gene does not affect the differentiation and survival of dopamine neurons, at least during embryonic development.
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
RAS oncogenes: the first 30 years
The knowledge that has accumulated since their discovery 30 years ago has been remarkable, and should pave the way for not only solving the outstanding issues regarding RAS biology, but also for developing efficacious drugs that could have a significant impact on cancer treatment.
The trk proto-oncogene encodes a receptor for nerve growth factor
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
These findings demonstrate that Trk is the primary mediator of the trophic actions of NGF in vivo and that this signalling pathway plays a crucial role in the development of both the peripheral and the central nervous systems.
Mammalian cyclin-dependent kinases.
Cdk1 is sufficient to drive the mammalian cell cycle
It is shown that mouse embryos lacking all interphase Cdks undergo organogenesis and develop to midgestation and that in the absence of interphaseCdks, Cdk1 can execute all the events that are required to drive cell division.